STATE OF RENAL FUNCTIONAL RESERVE IN WHITE RATS DURING PHYSIOLOGICAL COURSE OF PREGNANCY
https://doi.org/10.24884/1561-6274-2003-7-4-76-80
Abstract
THEAIM of the investigation was to study the state of renal functional reserve in rats during pregnancy. MATERIAL AND METHODS. The investigation was performed in 4 groups of white laboratory rats: groups 1 and 2 - non-pregnant rats with body mass 215-250 g, groups 3 and 4 - pregnant rats (second half of pregnancy, mass of the fetuses 3-5 g) with body mass 240-270 g. The value of renal functional reserve was determined by increased creatinine clearance between groups of animals under conditions of water loading (basal CFR values) and acute osmotic loading with 3% solution of sodium chloride (stimulated CFR values). The state of the tubular portion of the nephron was analyzed on the basis of investigating renal excretion of calcium, phosphates, osmotically active substances and protein. RESULTS. Itwas found that in rats with physiological course of pregnancy the value of renal functional reserve was increased which was followed by increased excretion of endogenous nitrates and nitrites. It was also shown that during physiological course of pregnancy the renal regulation of osmotic homeostasis was more exact. CONCLUSION. 1. The value of the renal functional reserve in rats increases during pregnancy. 2. Renal excretion of inorganic nitrogen oxides increases in rats during physiological development of pregnancy. 3. Renal mechanisms of regulation of osmotic homeostasis work more exactly in pregnant rats.
About the Authors
A. I. Gozhenko
Одесский государственный медицинский университет
Ukraine
Ukraine
S. I. Dolomatov
Одесский государственный медицинский университет
Ukraine
Ukraine
A. N. Sluchenko
Одесский государственный медицинский университет
Ukraine
Ukraine
E. A. Dolomatova
Одесский государственный медицинский университет
Ukraine
Ukraine
B. A. Nasibullin
Одесский государственный медицинский университет
Ukraine
Ukraine
References
1. Roberts М, Lindheimer MD, Davison JM. Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy. Am J Physiol 1996; 270(2): F338-F343
2. Fan L, Mukaddam-Daher S, Gutkowska J et al. Enhanced natriuretic response to intrarenal infusion of atrial natriuretic factor during ovine pregnancy. Am J Physiol 1996; 270(5): R1132-R1140
3. Bernard A, Thielemans N, Lauwerys R, van-Lierde M. Selective increase in the urinary excretion of protein 1 (Clara cell protein) and other low molecular weight proteins during normal pregnancy. Scand J Clin Lab Invest 1992; 52(8): 871-878
4. Faas MM, Schuiling GA, Klok PA et al. The glomerular filtration rate during pregnancy: saline infusion enhances the glomerular filtration rate in the pregnant rat. Kidney Blood Press Res 1996; 19(2): 121-127
5. Емченко НЛ, Цыганенко ОИ, Ковалевская TB. Универсальный метод определения нитратов в биосредах организма. Клин лаб диагностика 1994; (6):19-20
6. Дикусаров BB, Гоженко АИ. Состояние осморегулирующей функции почек при позднем токсикозе беременных. Bonp охр материнства и детства. 1984; (10): 52-56
7. Запорожан BH, Свирский AA, Гоженко АИ и др. Pe-нин-ангиотензин-альдостероновая система у беременных с гестозом. Медична хiмiя (Тернополь) 2001; 3(2): 55-57
8. Sturgiss SN, Wilkinson R, Davison JM. Renal reserve during human pregnancy. Am J Physiol 1996; 271(1): F16-F20
9. Гоженко АИ, Карчаускас ВЮ, Доломатов СИ. Влияние гиперосмотической и водной нагрузок на функциональное состояние почек белых крыс при экспериментальной нефропатии, вызванной хлоридом ртути. Нефрология 2002; 6(3):72-74
10. Гоженко АИ, Карчаускас ВЮ, Доломатов СИ, Доломатова EA, Пыхтев ДМ. Функция почек при кадмиевой нефропатии в условиях водной и солевой нагрузок. Нефрология 2002; 6(3):75-78.
11. Рябов СИ, Наточин ЮВ. Функциональная нефрология. Лань, СПб.: 1997
12. Реутов ВП, Сорокина ЕГ, Охотин BE, Косицын НС. Циклические превращения оксида азота в организме млекопитающих. Наука, М.: 1998
13. Godfrey М, Majid DS. Renal handling of circulating nitrates in anesthetized dogs. Am J Physiol 1998; 275(1): F68-F73
14. Гоженко Al. Роль оксида азота в молекулярно-клеточных механизмах функции почек. Укр биохим журнал 2002; 74(4а): 96
15. MurerH, HernandoN, Forsterl, Biber J. Proximaltubular phosphate reabsorption: molecular mechanisms. Physiol Rev 2000;80(4): 1373-1409
16. Zeballos GA, Bernstein RDJhompson Cl, Forfia PR. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 1995; 91(12): 2982-2988
17. Suto T, Losonczy G, Qiu C et al. Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO production. Kidney Int 1995; 48(4): 1272-1277
18. Murase T, Tian Y, Fang XY1 Verbalis JG. Synergistic effects of nitric oxide and prostaglandins on renal escape from vasopressin-induced antidiuresis. Am J Physiol 2003; 284(2): R354-R362
Review
For citations:
Gozhenko A.I., Dolomatov S.I., Sluchenko A.N., Dolomatova E.A., Nasibullin B.A. STATE OF RENAL FUNCTIONAL RESERVE IN WHITE RATS DURING PHYSIOLOGICAL COURSE OF PREGNANCY. Nephrology (Saint-Petersburg). 2003;7(4):76-80. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-4-76-80
Views:
342
Email this article 