MORPHOLOGICAL GROUNDS OF IMPAIRMENT OF THE KIDNEY FUNCTION DUE TO DISTURBED INFLOW TO THIS ORGAN

Abstract

THE AIM of the work was to establish structural bases of the impairment of the kidney functions under conditions of difficult blood flow to these organs. MATERIAL AND METHODS. Modelling of chronic renal ischemia was made by growing constriction of the aorta in 30 puppies. The animals were observed during the period from 6 months to 2 years. The level of blood inflow to the kidneys and blood pressure were measured, and the organs were investigated histologically, stereometrically and morphometrically. In the group of control there were 10 dogs of the corresponding age. RESULTS. It was found that constriction of the aorta due to less inflow of blood to the kidneys during certain time resulted in the development of a complex of adaptational and pathological alterations in their vascular system. The first ones appear as lower tone and atrophy of circulatory muscles of the renal arteries bringing the level of the development of the walls to conformity with the functional load, as well as transformation of some of them by the closing type, and the others - to the development of sclerosis and hyalinosis of the renal vessels. The latter is accompanied by disorders of hemocirculation in the blood basin of the kidneys and secondary alterations of glomerules and non-vascular structures of these organs. Renal glomerules were subject to sclerosis, while the renal parenchyma consisting of a system of tubules, to dystrophicand atrophic alterations. On its place there grows the stroma. CONCLUSION. All this complex of morphological alterations is a precondition for disturbaces of kidney functions, that can be observed in the clinic in patients with stenosing atherosclerosis of renal arteries.