СОВРЕМЕННЫЕ МЕТОДЫ МОДЕЛИРОВАНИЯ ОКСАЛАТНОГО НЕФРОЛИТИАЗА
https://doi.org/10.24884/1561-6274-2008-12-4-28-35
Аннотация
Настоящий обзор литературы посвящен современным методам моделирования оксалатного нефролитиаза. На сегодняшний день наиболее актуальными являются этиленгликолевая и гидроксипролиновая модели оксалатного нефролитиаза в различных вариациях. Кроме того, существуют методики, в которых в качестве основных реагентов выступают растворы оксалат-иона в сочетании с нефротоксичными веществами. Иногда нефролитиаз моделируют при помощи имплантированных под кожу мининасосов, которые напрямую дозируют в кровоток экспериментальных животных раствор щавелевой кислоты; а также путем резекции части тонкого кишечника. При моделировании оксалатного нефролитиаза важное внимание уделяется подбору лабораторных животных. Чаще всего используют нормальных крыс различных линий, а также крыс с врожденной гиперкальциурией. При этом предпочтительно использование самцов животных, поскольку у них вероятность развития нефролитиаза выше, чем у самок.
Об авторах
А. Ю. Жариков
Алтайский государственный медицинский университет, г.Барнаул
Россия
кафедра фармакологии
Россия
кафедра фармакологии
В. М. Брюханов
Алтайский государственный медицинский университет, г.Барнаул
Россия
кафедра фармакологии
Россия
кафедра фармакологии
Я. Ф. Зверев
Алтайский государственный медицинский университет, г.Барнаул
Россия
Россия
кафедра фармакологии
656038, г.Барнаул, пр.Ленина, 40; тел. (3852) 26-08-35
В. В. Лампатов
Алтайский государственный медицинский университет, г.Барнаул
Россия
кафедра фармакологии
Россия
кафедра фармакологии
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Рецензия
Для цитирования:
Жариков А.Ю., Брюханов В.М., Зверев Я.Ф., Лампатов В.В. СОВРЕМЕННЫЕ МЕТОДЫ МОДЕЛИРОВАНИЯ ОКСАЛАТНОГО НЕФРОЛИТИАЗА. Нефрология. 2008;12(4):28-35. https://doi.org/10.24884/1561-6274-2008-12-4-28-35
For citation:
Garicov A.U., Bruhanov V.M., Zverev Y.F., Lampatov V.V. CURRENT METHODS OF MODELING OF OXALATE NEPHROLYTHIASIS. Nephrology (Saint-Petersburg). 2008;12(4):28-35. (In Russ.) https://doi.org/10.24884/1561-6274-2008-12-4-28-35
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