PRORENIN AND RENIN – NEW TARGETS FOR RENO- AND CARDIOPROTECTIVE THERAPY
https://doi.org/10.24884/1561-6274-2009-13-1-15-20
Abstract
The today experimental data give us a reason to propose that in the case of the block of angiotensineconverting enzyme (ACE) and AT₁ – receptors to angiotensin II (A-II), prorenin and renin can show their profibrotic activity, acting through a specific prorenin/renin receptor. The profibrotic effect of prorenin/renin, even though mostly is noticed in the renal tissue, can cot be considered an isolated pathophysiological phenomena and P/R can connect with specific receptors on the surface of cardiomiocyte. At the present time take placethers clinical investigations of a new agent, which is the only representative of the direct inhibitors group of renin-aliskiren, which recently was approved by the FDA committee in USA as a medicine for arterial hypertension treatment. However, until present time it is not clear how much is the clinical significant is the blockade of (pro) renin receptors in accordance with the renal and cardiac fibrosis. The data of previous clinical investigations of aliskiren are very inspiring: the microalbumine level during its use decreases on 61% as compared with 50% during the ramipril intake. At present time take place two clinical investigations of the III phase on the evaluating the efficiency of aliskiren treatment in patients with chronic kidney disease (CKD): AVOID (Aliskiren in the Evaluation of Proteinuria in Diabetes) and AZTITUDE (Aliskiren Trial in Type 2 Diabetic Nephropathy). The results of these investigations should give new information on the therapy influence of aliskiren on the frequency and severityof diabetes. In such way, the opening of new mechanisms of functioning and meaning of renin – angiotensin- aldosterone system, probably shortly will have new ways of innovating reno- and cardioprotective therapy.
About the Authors
A. V. Smirnov
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
K. A. Smirnov
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Smirnov A.V., Smirnov K.A. PRORENIN AND RENIN – NEW TARGETS FOR RENO- AND CARDIOPROTECTIVE THERAPY. Nephrology (Saint-Petersburg). 2009;13(1):15-20. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-1-15-20
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