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КАРДИОПРОТЕКТИВНЫЕ ЭФФЕКТЫ D-ГОРМОНА У БОЛЬНЫХ С ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК: ОБЗОР ЛИТЕРАТУРЫ И СОБСТВЕННЫЕ ДАННЫЕ

https://doi.org/10.24884/1561-6274-2009-13-1-30-38

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Аннотация

Основной причиной смерти у пациентов с хронической болезнью почек являются сердечно-сосудистые болезни, риск развития которых повышается уже при незначительном снижении скорости клубочковой фильтрации. Причиной этого могут быть нарушения неэкскреторных функций почек, важное место среди которых занимает снижение синтеза в канальцах активной формы витамина D (ВД) – 1,25(OH)₂ витамина D – кальцитриола, который помимо регулирования фосфорно-кальциевого обмена оказывает важные эффекты на многие органы и ткани, включая сердечно-сосудистую систему. В обзоре рассмотрены результаты экспериментальных и клинических исследований, доказавших, что ВД тормозит активность ренин-ангиотензиновой системы, модулирует иммунную систему, что, в свою очередь, вызывает уменьшение системной воспалительной реакции, ингибирует пролиферацию и способствует дифференциации клеток. Эти механизмы приводят к торможению прогрессирования атеросклероза, гипертрофии левого желудочка, артериальной гипертензии, сердечной недостаточности и лежат в основе улучшения выживаемости пациентов, получающих лечение витамином D.

Об авторах

А. В. Смирнов
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Россия

кафедра пропедевтики внутренних болезней;

Научно-исследовательский институт нефрологии

197022 Санкт-Петербург, ул. Толстого 17, СПбГМУ им. акад. И.П.Павлова, тел.: 8-812-234-01-65



М. М. Волков
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Россия

кафедра пропедевтики внутренних болезней

197022 Санкт-Петербург, ул. Толстого 17, СПбГМУ им. акад. И.П.Павлова



В. А. Добронравов
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Россия

кафедра пропедевтики внутренних болезней;

Научно-исследовательский институт нефрологии

197022 Санкт-Петербург, ул. Толстого 17, СПбГМУ им. акад. И.П.Павлова



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Для цитирования:


Смирнов А.В., Волков М.М., Добронравов В.А. КАРДИОПРОТЕКТИВНЫЕ ЭФФЕКТЫ D-ГОРМОНА У БОЛЬНЫХ С ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК: ОБЗОР ЛИТЕРАТУРЫ И СОБСТВЕННЫЕ ДАННЫЕ. Нефрология. 2009;13(1):30-38. https://doi.org/10.24884/1561-6274-2009-13-1-30-38

For citation:


Smirnov A.V., Volkov M.M., Dobronravov V.A. CARDIOPROTECTIVE EFFECTS OF D-HORMONE IN PATIENTS WITH CHRONIC KIDNEY DISEASE: LITERATURE REVIEW AND PERSONAL DATA. Nephrology (Saint-Petersburg). 2009;13(1):30-38. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-1-30-38

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