THE ROLE OF CHRONIC INFLAMMATION IN PATHOGENESIS OF «UREMIC MALNUTRITION» IN CHRONIC HEMODIALYSIS PATIENTS WITH END STAGE RENAL DISEASE
https://doi.org/10.24884/1561-6274-2009-13-1-51-55
Abstract
The main causes of chronic inflammation in chronic hemodyalisis (HD) patients with end stage renal disease (ESRD) are described. The chronic inflammation factors, connected with hemodyalisis therapy in itself, as well as factors not related to hemodialysis are described. The connection between «uremic malnutrition» in chronic HD patients and chronic inflammation is shown in detail. In hemodyalisis patients with severe «uremic malnutrition» has a higher level of the main inflammation markers, than patients with no malnutrition signs. As a result of the fact that in chronic inflammation the active impact on the metabolism have anti-inflammatory cytokines, a proposition was made that chronic imflamation in hemodyalisis patients is one of the cause factors for the development of «uremic malnutrition» in this group of patients. Theoretically these interconnections seem very logical, although the results of the investigations in relation with chronic inflammation and the degree of «uremic malnutrition» in ESRD seem contradictory. The presence of this contradictions necessitate in further investigation in this direction.
About the Authors
A. A. Yakovenko
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
V. D. Yakovlev
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
Yu. Yu. Asanina
Городская поликлиника № 104, Санкт-Петербург
Russian Federation
Russian Federation
A. G. Kucher
Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Yakovenko A.A., Yakovlev V.D., Asanina Yu.Yu., Kucher A.G. THE ROLE OF CHRONIC INFLAMMATION IN PATHOGENESIS OF «UREMIC MALNUTRITION» IN CHRONIC HEMODIALYSIS PATIENTS WITH END STAGE RENAL DISEASE. Nephrology (Saint-Petersburg). 2009;13(1):51-55. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-1-51-55
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