СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МОДУЛЯТОРАХ ОКСАЛАТНОГО НЕФРОЛИТИАЗА. I. СТИМУЛЯТОРЫ КРИСТАЛЛИЗАЦИИ
Аннотация
В обзоре проанализированы факторы, способствующие кристаллизации оксалата кальция в почечных канальцах, и их роль в патогенезе мочекаменной болезни. Обсуждены общие представления о взаимодействии кристаллов с клетками эпителия канальцев почек. В качестве кандидатных кристалл-связывающих молекул рассмотрены сиаловая кислота, остеопонтин, фосфатидилсерин, белок, связанный с нуклеолином, аннексин II и гиалуронан, который, по-видимому, является основным индуктором кристаллизации. Поддержано мнение, согласно которому инициирующим моментом кристаллизации является обусловленное различными причинами повреждение почечного эпителия.
Об авторах
А. Ю. Жариков
Алтайский медицинский университет, г. Барнаул
Россия
Россия
кафедра фармакологии
656038, г.Барнаул, пр.Ленина, 40
Я. Ф. Зверев
Алтайский медицинский университет, г. Барнаул
Россия
Россия
кафедра фармакологии
656038, г.Барнаул, пр.Ленина, 40, (3852) 26-08-35
В. М. Брюханов
Алтайский медицинский университет, г. Барнаул
Россия
Россия
кафедра фармакологии
656038, г.Барнаул, пр.Ленина, 40
В. В. Лампатов
Алтайский медицинский университет, г. Барнаул
Россия
Россия
кафедра фармакологии
656038, г.Барнаул, пр.Ленина, 40
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Для цитирования:
Жариков А.Ю., Зверев Я.Ф., Брюханов В.М., Лампатов В.В. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МОДУЛЯТОРАХ ОКСАЛАТНОГО НЕФРОЛИТИАЗА. I. СТИМУЛЯТОРЫ КРИСТАЛЛИЗАЦИИ. Нефрология. 2009;13(1):56-72. https://doi.org/10.24884/1561-6274-2009-13-1-56-72
For citation:
Jaricov A.Yu., Zverev Y.F., Brukhanov V.M., Lampatov V.V. THE CURRENT CONCEPTIONS ABOUT THE MODULATORS OF THE OXALATE NEPHROLYTHIASIS. I. STIMULATORS OF CRYSTALLIZATION. Nephrology (Saint-Petersburg). 2009;13(1):56-72. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-1-56-72
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