THE EFFECTIVENESS OF PROSTATILEN IN ACUTE CYSTITIS (CLINICAL AND EXPERIMENTAL INVESTIGATION)
https://doi.org/10.24884/1561-6274-2009-13-2-92-95
Abstract
THE AIM of the investigation was to evaluate the effectiveness of the treatment of the patients with acute cystitis by rectal suppositories Prostatilen (Cytomed). MATERIALS AND METHODS. For the reproduction of acute cystitis in the urinary bladder cavity of the 60 white female rats of uncertain breed through the urethra was injected 0,5 ml of the suspension of dimexid and orthoksilol in ration 3:1 and exposition of 3 minutes. The treatment began on the next day and were divided into 4 groups. The rats of the 1st group (n=20) daily received prostatilen in intramuscular injections in the dose of 0,1 mg/100 g during 10 days, in the 2nd group during the same dates and intramuscular – fortum in the dose of 1,0 mg/ 100g, the third group (n=10) there was no treatment and the fourth group consisted of intact rats (n=10). On the next day after the last injection the rats were decapitated and had a macroscopic investigation of the urinary bladder and general urinary test, and weight coefficient was calculated. In clinical conditions the effectiveness of prostatilen was tested in treatment of 18 women from the age of 17 to 42, who were injected prostatilen in suppositories daily during 5 days at night. RESULTS. The treatment of prostatilen in experimental conditions gave a result comparable also in the weight coefficient data with those in treatment of fortum. The macroscopic evaluation of the urinary bladder showed a non significant increase in the wall thickness of the urinary bladder, the mucus lining did not change. The mucus of the non treated patents had edema and hyperemia with local bleedings. In clinical conditions the leucocyteuria and erythrocyteuria, as well as clinical signs of the disease, seized by 7-8th day from the beginning of the treatment. CONCLUSION. Experimental and clinical investigations showed the effectiveness of prostatilen in treatment of acute cystitis. Its use showedin monotherapy as well as in complex treatment of such patients, that in some cases its is possible to refuse from antibacterial therapy.
About the Authors
S. H. Al-Shukri
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. G. Gorbachev
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
S. Yu. Borovets
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Al-Shukri S.H., Gorbachev A.G., Borovets S.Yu. THE EFFECTIVENESS OF PROSTATILEN IN ACUTE CYSTITIS (CLINICAL AND EXPERIMENTAL INVESTIGATION). Nephrology (Saint-Petersburg). 2009;13(2):92-95. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-2-92-95
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