CALCIFICATION OF ABDOMINAL AORTA IN PATIENTS WITH CHRONIC KIDNEY DISEASE
https://doi.org/10.24884/1561-6274-2009-13-3-39-41
Abstract
Vascular calcification in patients with chronic kidney disease (CKD) progresses much faster and essentially worsens their survival rate. Calcification is an active process similar to bone formation, caused by transformation of smooth muscle cells in osteoblast-like ones under the influence of the adverse factors connected with CKD. The extent of calcification can be evaluated quantitatively by means of simple and informative X-ray examination of abdominal aorta. According to our data the severity of abdominal aorta calcification (AAC) in patients with CKD of 1-5 stages increases along with a decrease of glomerular filtration rate and is connected with progressive atherosclerosis and its risk factors, which in their turn, are associated with phosphorus-calcium imbalance. These factors dominate in calcification genesis in patients with CKD of 5d stage being on a hemodialysis. For the first time it is revealed, that more expressed AAC is interrelated with a decrease of mineral bone density. The long-term treatment by active forms of vitamin D is associated with the lessening of AAC extent in the patients receiving a hemodialysis.
About the Authors
M. M. Volkov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
L. A. Gordeyeva
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. V. Smirnov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Volkov M.M., Gordeyeva L.A., Smirnov A.V. CALCIFICATION OF ABDOMINAL AORTA IN PATIENTS WITH CHRONIC KIDNEY DISEASE. Nephrology (Saint-Petersburg). 2009;13(3):39-41. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-3-39-41
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