BIOCHEMICAL INDICES OF PHOSPHORUS-CALCIUM METABOLISM IN PATIENTS WITH CHRONIC KIDNEY DISEASE OF 1-5 STAGES
https://doi.org/10.24884/1561-6274-2009-13-3-49-51
Abstract
The risk of development of cardiovascular pathology increases in early stages of chronic kidney disease (CKD) and probably is connected with phosphorus-calcium metabolic disorder - an early diminution in concentration of the active form of vitamin D – 1.25 (OH)2D (calcitriol) and a rise of parathormone serum level. Pathogenesis of secondary heperparathyroidism, a decrease of calcitriol serum concentration is discussed in the review. The own data confirm an early disorder of hormonal regulation of phosphorus-calcium metabolism (from the 2nd stage of CKD). It is found for the first time, that the curve of phosphate serum level has the U-shaped form, i.e. phosphate values decrease in the 2nd stage of CKD and then quickly rise from the 4th stage. As CKD progresses there is a decrease of calcium and phosphate excretion with urine, possibly caused by a decreased calcitriol blood level.
About the Author
M. M. Volkov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Volkov M.M. BIOCHEMICAL INDICES OF PHOSPHORUS-CALCIUM METABOLISM IN PATIENTS WITH CHRONIC KIDNEY DISEASE OF 1-5 STAGES. Nephrology (Saint-Petersburg). 2009;13(3):49-51. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-3-49-51
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