THE IMPORTANCE OF INTERLEUKIN-6 IN THE PATHOGENESIS OF «UREMIC MALNUTRITION» IN PATIENTS WITH AND STAGE RENAL DISEASE BEING TREATED FOR CHRONIC HEMODIALYSIS
https://doi.org/10.24884/1561-6274-2010-14-1-56-62
Abstract
THE AIM of the study. Clarify the meaning of interleukin-6 in the pathogenesis of «uremic malnutrition» in patients with end-stage renal disease (ERSD) receiving chronic hemodialysis (HD). PATIENTS AND METHODS. We examined 86 patients with chronic kidney disease stage V receiving HD treatment, including 40 women and 46 men aged 52.2 ± 1.3 years. The cause of TRD in all cases was primary glomerulonephritis. All patients received hemodialysis treatment program for 6,4 ± 1,1 years. To estimate the daily intake of protein, fats, carbohydrates, total caloric intake, patients filled out food diaries for a week. To assess the nutritional status using kaliperometry and integrated dual frequency impedansometry using an instrument KM - AR - 01 firm «Diamond», Russia. In 78 patients to determine the spectrum of pro-inflammatory cytokines - interleukins - 2, 6, 8, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon gamma (IFN-g), TNF-αwith the help of Human 8-plex A panel (171-A11080 ) company Bio-rad, USA, a method based on the selective binding of defined cytokines and sorbed on the surface of micro particle antibodies. RESULTS. The interrelation between increased levels of interleukin-6 and «uremic malnutrition» in patients with end-stage renal failure receiving chronic hemodialysis was detected. Was shown that the increase of the duration of hemodialysis therapy was accompanied by increased signs of chronic inflammation. CONCLUSION. Increased IL-6 serum may be one of pathogenetic factors involved in the development of «uremic malnutrition» in patients with end-stage renal failure receiving chronic hemodialysis.
About the Authors
A. A. Yakovenko
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. G. Kucher
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. Sh. Rumyantsev
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Yakovenko A.A., Kucher A.G., Rumyantsev A.Sh. THE IMPORTANCE OF INTERLEUKIN-6 IN THE PATHOGENESIS OF «UREMIC MALNUTRITION» IN PATIENTS WITH AND STAGE RENAL DISEASE BEING TREATED FOR CHRONIC HEMODIALYSIS. Nephrology (Saint-Petersburg). 2010;14(1):56-62. (In Russ.) https://doi.org/10.24884/1561-6274-2010-14-1-56-62
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