COMPARATIVE STUDY OF DIURETIC AND SALURETIC ACTIVITY OF FUROSEMIDE AND IODINE-FUROSEMIDE IN EXPERIMENTS ON RATS

Abstract

THE AIM. Comparison of diuretic and saluretic activity furosemide and first received iodderivate furosemide in rats. MATERIAL AND METHODS. In experiments on rats comparing the effectiveness of one time subcutaneous injection of furosemide and iodine- furosemide in equimolar doses of 15 micromol / kg. Urine was collected during the day, determining the amount of urine output, excretion of sodium, potassium and chloride. RESULTS. Introduction of furosemide increased the daily output of 3.2 times, introduction of iodine-furosemide in 5.7 times in comparison with control. Excretion of sodium increase in 6.1 and 11.7 times, potassium - in 1.9 and 3.3 times respectively. With that the ratio of ions excreted by the action of the compared groupswas comparable. CONCLUSION. Founded on the basis of well-known diuretic drug furosemide new substance, 4-chloro-2-((5-iodofuran) methylamino)-5-sulfamilbenzoynaya acid (iodine-furosemide) in experiments on rats showed higher diuretic and saluretic activity against comparable rations excreted ions. This suggests that both compounds interact with the same type of target proteins in the renal tubules, revealing an identical mechanism of diuretic action, which differs only quantitatively.