THE VALUE OF CLASSICAL MORPHOLOGICAL FEATURES TO PREDICT THE COURSE OF TRANSITIONAL CELL CARCINOMA OF THE BLADDER

Abstract

THE AIM of the study the prognostic value of determining the depth of invasion and degree of differentiation of bladder cancer according to WHO recommendations editions 1973 and 2004. PATIENTS AND METHODS. Retrospectively studied the materials of clinical examination 115 patients (ratio of men to women was 9:1, mean age - 63 ± 1,9 years) operated on for transitional-cell bladder cancer (63 (54,8%) - transurethral resection, 14 (12.2%) radical cystectomy, 38 (33%) diagnostic TUR-biopsy followed by radiotherapy. During postsurgical histopathologic examination determined the depth of invasion and degree of differentiation of cancer from the standpoint of the two classification systems and to compare these results with postoperative survival. RESULTS. The low survival rate observed in patients with carcinomas located in the area of the triangle is pouring (rs = 0,64; p = 0,02), multiple tumors (rs = 0.62; p = 0,0.4), recurrent course of cancer (rs = 0.69; p = 0.018). The life expectancy of patients declined with increasing depth of germination of bladder cancer (r = 0.55; p = 0.01), as well as with increasing degree of anaplasia of carcinomas in the evaluation according to the classification in 1973 According to the WHO classification in 2004 the survival rate of patients with poorly differentiated cancer was significantly shorter compared with patients with highly differentiated carcinomas (t = 3.35; p = 0.007; U = 2.00; p = 0.017). CONCLUSION. The study showed that the two categories taken to date classification systems provide a variety of information regarding the flow of bladder cancer and should be used both systematization.