NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN CONTENT IN BLOOD AND URINE WITH COMPLICATED COURSE OF ACUTE CORONARY SYNDROME
Abstract
THE AIM: to study levels of NGAL in the blood serum (s-NGAL) and in the urine (u-NGAL) and their clinical relevance to the complicated clinical course of acute coronary syndrome (ACS) during hospital stay. PATIENTS AND METHODS. 113 patients were examined (81 males и 32 females, average age 59,5±9,6 years) and 59 were diagnosed ACS with ST segment rise (ACS-STR), 54 - without ST segment rise (ACSwSTR). During the first three days of hospital stay the following parameters were measured: s-NGAL and u-NGAL content and serum creatinine (sCr). Throughout the hospital stay, frequency of complications was observed and analysed. RESULTS. s-NGAL and u-NGAL levels at ACS-STR [209,2 (146,79; 489,48) and 6,8 (1,8; 30,78) respectively] were higher than at ACSwSTR [192,3 (124,7; 276) and 3,2, (1,8; 5,73), р=0,136 and р=0,009 respectively]. Acute kidney injury (AKI) was diagnosed upon the recommendations of KDIGO by sCR index for 11 ACS patients. Higher s-NGAL and u-NGAL levels were diagnosed for ACS patients with AKI [422,04 (166,82; 768,92) and 21,8 (2,31; 64,74)] in contrast to patients not having AKI [194,61 (133,15; 338,35) and 3,9 (1,8; 8,6), р=0,06 and р=0,09 respectively), however differences didn’t reach a statistical significance. 53 patients had a complicated course of ACS. For these patients median s-NGAL indexes [266,0 (144,39; 508,2)] were accurately half as large again than for the patients who did not develop complications [172,61 (132,3; 262,68)] (р=0,02). Nevertheless, u-NGAL content for both patients with complicated course [3,81 (1,81; 10,09)] and patients with non-complicated ACS course [4,35 (1,79; 10,43)] was comparable (р=0,9). CONCLUSION. ACS patients, who developed complications, got a higher s-NGAL level, as compared to the patients with non-complicated course.
About the Authors
M. A. Shalenkova
Municipal State Clinical Hospital №38
Russian Federation
Russian Federation
Z. D. Mikhailova
Municipal State Clinical Hospital №38
Russian Federation
Russian Federation
P. F. Klimkin
Municipal State Clinical Hospital №38
Russian Federation
Russian Federation
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For citations:
Shalenkova M.A., Mikhailova Z.D., Klimkin P.F. NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN CONTENT IN BLOOD AND URINE WITH COMPLICATED COURSE OF ACUTE CORONARY SYNDROME. Nephrology (Saint-Petersburg). 2015;19(6):39-44. (In Russ.)
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