The rate of different etiology chronic kidney disease progression in children
Abstract
RELEVANCE. Determination of nephropathy progression rate and reveal of early nephrosclerosis development clinical markers are extremely important for evaluation of chronic kidney disease prognosis and use of preventive therapeutic possibilities. THE AIM: to define regularities of progression to the CKD 3 stage in children with immune and non-immune nephropathies. PATIENTS AND METHODS. Due to retrospective analysis of 145 cases of children with immune CKD (steroid resistant nephrotic syndrome, n=75) and non-immune CKD (congenital nephritis, reflux-nephropathy, cystic disease, congenital kidney abnormalities, n=70) GFR dynamics was analyzed by Kaplan-Meier method from the onset of disease till age of CKD 3 stage. RESULTS. Established period for achievement CKD 3 stage depends on degree of proteinuria and arterial hypertension. Efficacy of selective inmmusupresive therapy in SRNS provides no 5-years GFR decline in 100% cases. In patients with non-immune nephropathies the highest rate of progression (to GFR lower 60 ml/min) was found in children with 2 stage arterial hypertension combined with low (less than 1 g/days), and moderated (1-2 g/days) proteinuria. CONCLUSION. Therefore, possibility of adverse outcomes progression rate evaluation in children with CKD promotes the optimization of therapeutic tactics and significantly influences on delay of kidney functions declining.
About the Authors
Olga Komarova
Scientific center of children’s health of Scientific research Institute of pediatrics
Russian Federation
Russian Federation
Alexey Tsygin
Scientific center of children’s health of Scientific research Institute of pediatrics
Russian Federation
Russian Federation
Leyla Namazova-Baranova
Scientific center of children’s health of Scientific research Institute of pediatrics
Russian Federation
Russian Federation
Alexander Baranov
Scientific center of children’s health of Scientific research Institute of pediatrics
Russian Federation
Russian Federation
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Review
For citations:
Komarova O., Tsygin A., Namazova-Baranova L., Baranov A. The rate of different etiology chronic kidney disease progression in children. Nephrology (Saint-Petersburg). 2016;20(2):53-58. (In Russ.)
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