Креатинин в современной оценке функционального состояния почек (обзор литературы и собственные данные)

Скорость клубочковой фильтрации (СКФ) является общепризнанным показателем функционального состояния почек. В медицинской практике существуют различные подходы для измерения СКФ. Однако, несмотря на почти столетнюю историю, далеко не все методологические проблемы оценки СКФ в клинической практике решены. Наиболее физиологически обоснованные («референтные») методы неприемлемы в рутинной практике из-за сложности и дороговизны. Клиницистам приходится опираться в основном на результаты суррогатных способов, большинство из которых в качестве гломерулотропного тест-агента предполагают использование эндогенного креатинина. Поэтому точность определения концентрации этого метаболита в биологических средах (особенно в сыворотке крови) зачастую решающим образом определяет надежность оценки СКФ. Производители наборов реагентов для определения креатинина должны принимать во внимание современные требования к точности и прослеживаемости результатов измерений и обеспечивать соответствие своей продукции международным нормам.

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