Glomerular filtration rate seasonal variations in men under 60 years old within acute and subacute period of myocardial infarction

The aim. Evaluation of renal function variations during different year seasons in men under 60 years old within acute and subacute phases of myocardial infarction (MI) to prevent dysfunction and enhance forecasting.

Patients and methods. Examination and treatment results analyses of 412 men with MI under 60 y.o. for the period of 2000-2015 who had 30-59 mL/ min/1,73 m² calculated glomerular filtration rate (GFR, CKD-EPI 2009, modification 2011) at the end of the third week from the disease onset (61 patients) and more than 60 mL/min/1,73 m² respective-ly (315 patients) had been conducted. Renal function changes were assessed during treatment in the first 48 hours and at the end of the third week from the MI onset in patients groups that were combined aligning to the climatic seasons of the year founded on average daily air tem-perature of St. Petersburg, Russia changes. Variations of renal dysfunction (RD) development simulation in different year seasons corresponding to the end of the third week of the disease were conducted with the use of classification trees methodology.

Results. Reliable evidence of creatinine and GFR level changes depending on the seasonal variances have been identified for the early periods of the MI development. An ef-fective prognostic algorithm with efficiency as high as 62 % for patients risk groups separation among men under 60 y.o. with MI potent to RD development at the end of the third week of disease was created.

Conclusions. Higher creatinine levels and low levels of GFR in men under 60 y.o. with MI are being observed in spring and winter. The risk group for RD development at the end of the MI subacute period represents smokers in summer and autumn; chronic heart failure history patients in winter; patients with diastolic arterial blood pressure in the MI acute period of 90 mm Hg and more in spring. Prescription of medicinal products with nephroprotective features starting from the first hours of MI development in this group of pa-tients is beneficial.

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