Features of cognitive impairment in patients with chronic kidney disease depending on the presence of arterial hypertension
Abstract
THE AIM: to identify cognitive dysfunctions relationship with arterial hypertension in young and middle aged patients with chronic kidney disease. PATIENTS AND METHODS. 108 young and middle aged patients with chronic glomerulonephritis of 1-3 stages chronic kidney disease were examined. 71 (65.7%) patients were diagnosed chronic glomerulonephritis which was proved morphologically. Cognitive dysfunctions were assessed with MMSE survey and software package Status PF. All the patients were performed 24-hour blood pressure monitoring tested. RESULTS. All the patients at the 1st stage were tested with MMSE survey, cognitive dysfunctions like pre-demension state were identified in 3 (2,7%) patients. These patients were excluded from the study. 65 patients (60,2%) were diagnosed arterial hypertension. The patients with chronic kidney disease demonstrated statistically significant positive correlation with neurodynamic indices and average systolic and diastolic blood pressure indices at day and night time. Positive correlation between average exposure dose of visual-motor coordination and morning systolic blood pressure level was identified (r=0,29 p=0,02). The analysis demonstrates the 24-hour blood pressure indices correlation with the reaction to the moving object. The research revealed statistically significant differences between minimum and average exposure dose of simple visual motor reaction; minimum and average exposure dose of complex visual motor reaction (p=0,012; p=0,024) by comparison of groups with AH and without AH. The mechanic memory span and the span of attention were significantly less in the group of patients with arterial hypertension comparing to the group without arterial hypertension. CONCLUSION. Patients with chronic kidney disease of 1-3 stages and concomitant arterial hypertension demonstrated lower neurodynamic, attention and memory indices comparing to the group without arterial hypertension.
About the Authors
N. V. Fomina
Kemerovo state medical academy
Russian Federation
Russian Federation
M. V. Egorova
Kemerovo state medical academy
Russian Federation
Russian Federation
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For citations:
Fomina N.V., Egorova M.V. Features of cognitive impairment in patients with chronic kidney disease depending on the presence of arterial hypertension. Nephrology (Saint-Petersburg). 2016;20(5):62-68. (In Russ.)
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