Cryoglobulinemic vasculitis associated with HCV infection: still a problem?
S. Yu. Milovanova,
L. V. Lysenko (Kozlovskaya),
L. Yu. Milovanova,
D. T. Abdurahmanov,
M. V. Taranova,
A. V. Volkov https://doi.org/10.36485/1561-6274-2022-26-3-30-39
Abstract
The review presents the main data on the problem of cryoglobulinemic vasculitis associated with HCV infection. The options for the course are considered, and modern diagnostic criteria, the choice of tactics, and the effectiveness of various treatment regimens are presented. The use of modern antiviral drugs makes it possible to achieve the eradication of the virus in 95 % of patients. However, in some patients, clinical and immunologic markers of vasculitis persist despite viral clearance. The article discusses the concept that the persistence of B-cell clones after achieving a sustained virological response may underlie the pathogenesis of HCV-independent CV reactivation.
About the Authors
S. Yu. Milovanova
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Svetlana Yu. Milovanova, Professor, Doctor of Medical Sciences
Department of Internal, Occupational Diseases and Rheumatology
119435
Rossolimo str., 11, b. 4-5
Moscow
tel. +79031435050
L. V. Lysenko (Kozlovskaya)
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Lydia V. Lysenko (Kozlovskaya), Doctor of Medical Sciences
Department of Internal, Occupational Diseases and Rheumatology
119435
Rossolimo str., 11, b. 4-5
Moscow
phone: +79163044629
L. Yu. Milovanova
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Lyudmila Yu. Milovanova, Professor, Doctor of Medical Sciences
Department of Internal, Occupational Diseases and Rheumatology
119435
Rossolimo str., 11, b. 4-5
Moscow
phone: +79161641400
D. T. Abdurahmanov
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Jamal T. Abdurakhmanov, Professor, Doctor of Medical Sciences
Department of Internal, Occupational Diseases and Rheumatology
119435
Rossolimo str., 11, b. 4-5
Moscow
phone: +79262803431
M. V. Taranova
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Marina V. Taranova, Associate Professor, Candidate of Medical Sciences
Department of Internal, Occupational Diseases and Rheumatology
119435
Rossolimo str., 11, b. 4-5
Moscow
phone: +79166151255
A. V. Volkov
First Moscow State Medical University named after I. I. Sechenov (Sechenov University)
Russian Federation
Russian Federation
Alekseй V. Volkov, Associate professor, MD, PhD
Department of Psychiatry and Narcology
119435
ul. Rossolimo, D. 11, b. 9
Moscow
phone: +79035892937
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Review
For citations:
Milovanova S.Yu., Lysenko (Kozlovskaya) L.V., Milovanova L.Yu., Abdurahmanov D.T., Taranova M.V., Volkov A.V. Cryoglobulinemic vasculitis associated with HCV infection: still a problem? Nephrology (Saint-Petersburg). 2022;26(3):30-39. (In Russ.) https://doi.org/10.36485/1561-6274-2022-26-3-30-39
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