Arterial hypertension and salt intake: contribution to cardiac remodeling
Abstract
THE AIM: to examine the effect of diets with different contents of sodium chloride on blood pressure (BP), remodeling of the myocardium and the parameters of sodium homeostasis in spontaneously hypertensive rats (SHR). MATERIAL AND METHODS. We studied two groups of animals. Firs group received 2 months diet containing 0.34% NaCl, second - high salt diet (8.0 %) NaCl. The blood pressure (BP) was recorded at the end of the observation period. In serum and in daily urine sodium concentration was determined. The study of morphological changes in the myocardium was performed on the light-optical level. RESULTS. The level of BP did not differ between groups, myocardial mass index, index of left ventricular mass, sodium concentration in the urine, daily urine volume and sodium excretion were higher in animals fed a diet containing 8 % NaCl. In rats from this group increasing of the severity of hypertrophy of cardiomyocytes fibers, mild perivascular fibrosis and moderate hypertrophy of smooth muscle cells of the vessel walls were revealed. CONCLUSION. Results of the study suggest that the high sodium chloride diet in SHR rats leads to a unique profile of myocardial remodeling, which is not determined exclusively by the increase of blood pressure.
About the Authors
M. M. Parastaeva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
O. N. Beresneva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
G. T. Ivanova
Institute of Physiology named after I.P. Pavlov of the Russian Academy of Sciences
Russian Federation
Russian Federation
N. V. Shwed
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
A. G. Kucher
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
I. M. Zubina
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
I. G. Kayukov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Parastaeva M.M., Beresneva O.N., Ivanova G.T., Shwed N.V., Kucher A.G., Zubina I.M., Kayukov I.G. Arterial hypertension and salt intake: contribution to cardiac remodeling. Nephrology (Saint-Petersburg). 2016;20(5):97-105. (In Russ.)
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