THE EFFECT OF EARLY POSTTRANSPLANT PLASMAPHERESIS ON LATE RESULTS OF KIDNEYS GRAFTING IN CHILDREN
Abstract
THE AIM: to estimate an influence of plasmapheresis (PA), carried in early postoperative period, on 15-year results of renal transplantation. PATIENTS AND METHODS. In 32 children operated at 1995-1996 years PA was not carried. This group was called “before PA”. In 32 children, operated at 1996-1997 years, PA was carried in early postoperative period. This group was called “PA”. In 31 patients operated at 1997-1998 years, PA was not carried, but their inductive immunosuppression was intensified with ATG, introduction of cyclosporine microemulsion and CellSept. This group was called “after PA”. RESULTS. Actuarial survival of both patients and grafts was highest in group “PA” and “after PA” compared to other groups. The difference was statistically significant. CONCLUSION: plasmapheresis done in the early posttransplant period may have a positive influence on long-term outcomes o f kidney transplantation in children.
About the Authors
M. M. Kaabak
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Prof. Michael M. Kaabak MD, DMedSci.
Chief of Department for kidney transplantation.
V. A. Goryajnov
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Victor A. Goryainov MD, DMedSci.
Department for kidney transplantation.
119991 Russia, Moscow, Abricosovsky 2.
A. K. Zokojev
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Allan K. Zokoev: MD, DMedSci.
Department for kidney transplantation.
N. N. Babenko
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Nadezhda N. Babenko, MD.,CMedSci,
Department for kidney transplantation.
Y. N. Vjyunkova
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Yuly N. Viewnkova, MD, pediatr in department for kidney transplantation.
Department for kidney transplantation
M. M. Morozova
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Marguerite M. Morozova, MD, CMed SCI, LRF.
Department for Pathological anatomy.
A. G. Aganesov
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Allan K. Zokoev: MD, DMedSci.
Department for kidney transplantation
E. N. Platova
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Helene N. Platova, MD, CMS, LRF.
Department for clinical physiology, instrumental and radial diagnostic
O. V. Dymova
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Olga V. Dymova DM, CMedSCI.
Laboratory for clinical biochemistry/
V. V. Panin
Russian Scientific Center of Surgery named after academician B.V. Petrovsky
Russian Federation
Russian Federation
Basil V. Panin, MD, CMS, SRF.
Laboratory for clinical biochemistry
References
1. Бикбов БТ, Томилина НА. Заместительная терапия больных с хронической почечной недостаточностью методами перитонеального диализа и трансплантации почки в Россий ской Федерации в 1998-2011 г. (Отчет по данным Российского регистра заместительной почечной терапии. Часть вторая). Нефрология и диализ 2014; 16 (2): 192-227 [Bikbov BT, Tomilina NA. Zamestitel`naia terapiia bol`ny`kh s khronicheskoi pochechnoi nedostatochnost`iu metodami peritoneal`nogo dializa i transplantatcii pochki v Rossiiskoi Federatcii v 1998-2011 g. (Otchet po danny`m Rossiiskogo registra zamestitel`noi pochechnoi terapii. Chast` vtoraia). Nefrologiia i dializ 2014; 16 (2): 192-227]
2. Каабак ММ, Горяйнов ВА, Соловьева ИН и др. Влияние посттрансплантационного плазмафереза на результаты пересадки трупной почки. Хирургия 2002; (12): 30-34 [Kaabak MM, Goriai`nov VA, Solov`eva IN i dr. Vliianie posttransplantatcionnogo plazmafereza na rezul`taty` peresadki trupnoi` pochki. Hirurgiia 2002; (12): 30-34]
3. Горяйнов ВА, Каабак ММ, Молчанова ЕА. Плазмаферез для лечения реперфузионной травмы при пересадке почки – влияние на ближайшие и отдалённые результаты. Вестник РАМН 2002; (5): 43-45 [Goriai`nov VA, Kaabak MM, Molchanova EA. Plazmaferez dlia lecheniia reperfuzionnoi` travmy` pri peresadke pochki – vliianie na blizhai`shie i otdalyonny`e rezul`taty`. Vestneyk RAMN 2002; (5): 43-45]
4. Синютин АА. Влияние послеоперационного плазмафереза на функцию и внутриорганный кровоток почечного аллотрансплантата. Автореф. ... дис. кандидат медицинских наук. М., 2005
5. Салимов ЭЛ. Эффективность раннего плазмафереза после пересадки почки. Автореф. ... дис. кандидат медицинских наук. М., 2005 [Salimov E`L. E`ffektivnost` rannego plazmafereza posle peresadki pochki. Avtoreferat dissertatcii na soiskanie uchyonoi` stepeni kandidata meditcinskikh nauk. Moskva, 2005]
6. Каабак ММ, Горяйнов ВА, Зокоев АК и др. Десятилетний опыт применения раннего плазмафереза после пересадки почки. Вестн трансплантол и искусственных органов 2009; 11 (1): 28-33 [Kaabak MM, Goriai`nov VA, Zokoev AK i dr. Desiatiletneyi` opy`t primeneniia rannego plazmafereza posle peresadki pochki. Vestneyk transplantologii i iskusstvenny`kh organov 2009; 11 (1): 28-33]
7. Land W, Zweker JL. Prevention of reperfusion-induced, free radical-mediated acute endotelial injury by superoxide dismutase as an effective tool to delay/prevent chronic renal allograft failure: a review. Transplant Proc 1997; 29(6): 2567-2568
8. Hauet T, Mothes D, Goujon JM et al. Trimetazidine prevents renal injury in the isolated perfused pig kidney exposed to prolonged cold ischemia. Transplantation 1997; 15, 64(7), 1082-1086
9. Nagel E, Meyer zu Vilzendorf A, Bartels M et al. Antioxidative vitamins in prevention of ischemia/reperfusion injury. Int J Vitamin Nutr Res 1997; 67 (5): 298-306
10. Ермолов АС, Гуляев ВА, Погребниченко ИВ и др. Доноры с небьющимся сердцем при трансплантации печени. Вестн трансплантол и искусственных органов 2005; (4): 4351 [Ermolov AS, Guliaev VA, Pogrebnichenko IV i dr. Donory` s neb`iushchimsia serdtcem pri transplantatcii pecheni. Vestneyk transplantologii i iskusstvenny`kh organov 2005; (4): 43-51]
11. Kramer AA, Postler G, Salhab KF et al. Renal ishemia/ reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability. Kidney Int 1999; 55: 2362-2367
12. Krause SM, Walsh TF, Greenlee WJ et al. Renal Protection by a Dual ETa/ETb Endothelin Antagonist, L-754,142, after Aortic Cross-Clamping in the Dog. J Am Soc Nephrol 1997; 8 (7): 1061-1071
13. Ruschitzka F, Shaw S, Gycl D et al. Endothelial dysfunction in acute renal failure: role of circulating and tissue endothelin-1. J Am Soc Nephrol 1999 (10): 953-962
14. Каабак ММ, Горяйнов ВА, Дьяченко ИВ. Использование плазмафереза для коррекции реперфузионной травмы при пересадке почек. Нефрология и диализ 2001; (3): 345354 [Kaabak MM, Goriai`nov VA, D`iachenko IV. Ispol`zovanie plazmafereza dlia korrektcii reperfuzionnoi` travmy` pri peresadke pochek. Nefrologiia i dializ 2001; (3): 345-354]
15. Горяйнов ВА, Каабак ММ, Бабенко НН и др. Аллотрансплантация родственных почек у детей. Хирургия. Журн им. Н.И. Пирогова 2008; (6): 58-62 [Goriai`nov VA, Kaabak MM, Babenko NN i dr. Allotransplantatciia rodstvenny`kh pochek u detei`. Hirurgiia. Zhurnal im. N.I.Pirogova 2008; (6): 58-62]
16. Садовников ВИ, Сандриков ВА, Каабак ММ. Влияние плазмафереза на функцию и внутриорганный кровоток почечного аллотрансплантата в раннем послеоперационном периоде. Вестн трансплантол и искусственных органов 2003; (3): 21 [Sadovnikov VI, Sandrikov VA, Kaabak MM. Vliianie plazmafereza na funktciiu i vnutriorganny`i` krovotok pochechnogo allotransplantata v rannem posleoperatcionnom periode. Vestneyk transplantologii i iskusstvenny`khorganov 2003; (3): 21]
Review
For citations:
Kaabak M.M., Goryajnov V.A., Zokojev A.K., Babenko N.N., Vjyunkova Y.N., Morozova M.M., Aganesov A.G., Platova E.N., Dymova O.V., Panin V.V. THE EFFECT OF EARLY POSTTRANSPLANT PLASMAPHERESIS ON LATE RESULTS OF KIDNEYS GRAFTING IN CHILDREN. Nephrology (Saint-Petersburg). 2016;20(6):75-81. (In Russ.)
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