DIAGNOSTIC VALUE OF BLOOD NGAL, COMPLEMENT PROTEINS C3 AND C4, IMMUNOGLOBULINS IN CHILDREN WITH HEMOLYTIC-UREMIC SYNDROME
https://doi.org/10.24884/1561-6274-2017-3-39-46
Abstract
The aim: to determine changes of levels of blood neutrophil gelatinase-associated lipocalin (NGAL), complement proteins C3 and C4, immunoglobulins in children with hemolytic-uremic syndrome (HUS) and to find the relationship between them and factors determining the severity of kidney injury. A prospective study included 159 children: 35 in the acute phase of HUS, 124 – after HUS, at least 6 months after discharge from the hospital and 28 healthy children. NGAL was elevated in all children with HUS more pronounced in those who required renal replacement therapy. Activation of the alternative pathway of the complement system in HUS D «+» due to reduced C3 and normal C4 levels was found. The degree of increasing NGAL and decreasing complement C3 has a close correlation with parameters reflecting the severity of renal damage. At the onset of HUS the decreasing of IgG and IgA with normal IgM levels was found, indicating inadequate humoral protection and the risks of infectious complications.
About the Authors
S. V. Baiko
Belarusian State Medical University
Belarus
Belarus
Dr., MD, PhD, 1st Department of Pediatrics,
220016, Minsk, Narochanskaya St., 17
A. V. Sukalo
Belarusian State Medical University;
Belarusian National Academy of Sciences
Belarus
Belarus
Prof., MD, PhD, DMedSci, Acad., 1st Department of Pediatrics,
220016, Minsk, Narochanskaya St., 17
A. I. Burackovski
Institute of Bioorganic Chemistry, Belarusian National Academy of Sciences
Belarus
Belarus
PhD,
220141, Minsk, Kuprevich Str. 5/2
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Review
For citations:
Baiko S.V., Sukalo A.V., Burackovski A.I. DIAGNOSTIC VALUE OF BLOOD NGAL, COMPLEMENT PROTEINS C3 AND C4, IMMUNOGLOBULINS IN CHILDREN WITH HEMOLYTIC-UREMIC SYNDROME. Nephrology (Saint-Petersburg). 2017;21(3):39-46. (In Russ.) https://doi.org/10.24884/1561-6274-2017-3-39-46
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