EVALUATION OF THE INFLUENCE OF SERUM RESISTIN IN CLINICAL AND MORPHOLOGICAL MANIFESTATIONS OF CHRONIC GLOMERULONEPHRITIS

THE AIM: to research the effect of serum concentrations of resistin on various clinical and morphological manifestations of chronic glomerulonephritis.

PATIENTS AND METHODS. The study included 80 patients with chronic glomerulonephritis, of which 45 patients had IgA-nephropathy, 17 – focal segmental glomerulosclerosis, 10 – membranous nephropathy, 6 – minimal change disease, 1 – IgM-nephropathy, 1 – type I membrane-proliferative glomerulonephritis. 30 patients had a nephrotic variant of nephritis, 50 patients had a nephritic variant (hypertonic). The average age of the patients was 36.2 ± 1.27 years, of which 51 were males and 29 females. The level of the creatinine of blood, urea was estimated, glomerular filtration rate was (CKD-EPI) was calculated. The level of resistin in serum was also determined. All patients underwent needle nephrobiopsy (optical microscopy, immunofluorescent assay, electron microscopy).

RESULTS. Statistically significant correlations of resistin were detected with respect to the initial proteinuria of a single case (r = 0.32, p = 0.04) and daily proteinuria (r = 0.39, p = 0.001). Dependence of resistin and parameters reflecting the renal function: urea, creatinine, GFR, determined initially and after 12 months, was not identified, nor was there a correlation with rates of decrease / increase of these parameters after 12 months. When performing logistic regression analysis, it was shown that, in nephritic and nephrotic variants, the level of resistin increases the probability of developing a number of morphological changes in the glomerulus exclusively in the renal glomeruli, in particular, the risk of detection of segmental sclerosis, predominantly mesangial deposition of immunoglobulin deposits, primarily IgA.

CONCLUSION. In the course of the study, there was no association of resistin with renal function factors (creatinine, urea, GFR), both initially and against a background of 12 months of observation and treatment. It has been shown that as the serum concentration of resistin increases, the level of proteinuria increases, and the likelihood of developing glomerular morphological changes, generally reflecting the severity of the glomerular lesion, increases. 

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