SOME PECULIARITIES OF KIDNEY DISORDERS IN WOMEN WITH PREEKLAMPSIA AND OBESITY
https://doi.org/10.24884/1561-6274-2017-21-5-54-63
Abstract
THE AIM: to study the functional capacity of the kidneys in women with alimentary obesity under pre-eclampsia.
PATIENTS AND METHODS. The study included 145 pregnant women in a period of 37-40 weeks. The first group included 60 pregnant women with preeclampsia of moderate severity. In the second – 63 pregnant women with preeclampsia of moderate severity and alimentary obesity. Control group – 22 women with physiological pregnancy. All pregnant women have assessed the rate of glomerular filtration, β2-microglobulin in urine, studied the osmoregulating function of the kidneys, colloid-oncotic pressure, as well as the concentration of leptin.
RESULTS of the studies showed that 79.4% of women with preeclampsia of moderate severity had a violation of the functional state of the kidneys. In 86.7% of patients from this group, there were quite pronounced violations of colloid-oncotic homeostasis. In 93.7% of women with preeclampsia of moderate severity and obesity, violations of osmotic and metabolic functions of the kidneys were more pronounced than in the first group.
CONCLUSION. Combined disorders of colloid-oncotic pressure and the syndrome of “hypoperfusion” leading to the transformation of osmotic and metabolic functions of the kidneys are the cause of the renal dysfunction formation in women with preeclampsia and obesity, involving in the pathological process of adaptation and regulatory systems of pregnant women.
About the Authors
S. S. Tumanyan
Rostov State Medical University
Russian Federation
Russian Federation
MD, Department of Obstetrics and Gynecology No. 1, assistant Professor,
344022, Rostov-on-Don, per. Nakhichevansky, 29
A. N. Rymashevsky
Rostov State Medical University
Russian Federation
Russian Federation
Prof., MD, PhD, DMedSci., Department of Obstetrics and Gynecology No. 1,
344022, Rostov-on-Don, per. Nakhichevansky, 29
S. V. Tumanyan
Rostov State Medical University
Russian Federation
Russian Federation
Prof., MD, PhD, DMedSci, Department of Anesthesiology and Reanimatology,
344022, Rostov-on-Don, per. Nakhichevan, 29
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Review
For citations:
Tumanyan S.S., Rymashevsky A.N., Tumanyan S.V. SOME PECULIARITIES OF KIDNEY DISORDERS IN WOMEN WITH PREEKLAMPSIA AND OBESITY. Nephrology (Saint-Petersburg). 2017;21(5):48-52. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-5-54-63
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