Experience of application of eculizumab the child with atypical haemolytic uraemic syndrome
Abstract
Аtypical hemolytic uremic syndrome (aHUS) - genetically progressive disease with a very high risk of sudden death and irreversible and debilitating damage to vital organs. In the basis of aHUS is thrombotic microangiopathy associated with uncontrolled activation of the complement system. A new therapeutic option in the world today has been the use of monoclonal antibodies - inhibitors of the complement system (complement component C5 blocker). The only representative of this group is the drug eculizumab. In the article presented their own experience of eculizumab the child with aHUS.
About the Authors
T. P. Makarova
Казанский государственный медицинский университет ; Детская Республиканская клиническая больница Министерства здравоохранения Республики Татарстан
Russian Federation
Russian Federation
G. R. Davletbaeva
Казанский государственный медицинский университет ; Детская Республиканская клиническая больница Министерства здравоохранения Республики Татарстан
Russian Federation
Russian Federation
L. V. Poladova
Казанский государственный медицинский университет ; Детская Республиканская клиническая больница Министерства здравоохранения Республики Татарстан
Russian Federation
Russian Federation
N. V. Osipova
Казанский государственный медицинский университет ; Детская Республиканская клиническая больница Министерства здравоохранения Республики Татарстан
Russian Federation
Russian Federation
Yu. S. Melnikova
Казанский государственный медицинский университет ; Детская Республиканская клиническая больница Министерства здравоохранения Республики Татарстан
Russian Federation
Russian Federation
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Review
For citations:
Makarova T.P., Davletbaeva G.R., Poladova L.V., Osipova N.V., Melnikova Yu.S. Experience of application of eculizumab the child with atypical haemolytic uraemic syndrome. Nephrology (Saint-Petersburg). 2014;18(3):84-88. (In Russ.)
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