DYNAMICS OF MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES IN KIDNEY TISSUE DURING URETERAL OBSTRUCTION IN THE EXPERIMENT
https://doi.org/10.24884/1561-6274-2017-21-5-100-108
Abstract
THE AIM: the comparative study of morphological changes in kidney tissue with mechanical ureteral obstruction in the experiment at the time of 7, 14, 21 days.
Matherials and methods. The study of the dynamics of the morphological changes in the kidney showed that in the first 7 days after obstruction, there are compensatory reactions from the tubular apparatus of the medulla of the kidneys and minimal development of interstitial fibrosis.
Results. In the subsequent terms (14-21 days), compensatory phenomena in the epithelial cells of the tubules are disrupted autoregulatory mechanisms of adaptation, which is manifested in the phenomena of protein, hydrops dystrophy, atrophy, cystic transformation of epithelial cells of the tubules of the cortex and medulla layers, and the appearance of large zones of interstitial fibrosis of the stroma.
CONCLUSION. Obtained data make it possible to consider that the optimal period for performing surgical interventions, with obstructive uropathy, is the first week from the beginning of the development of the pathological process since this will prevent further development of dystrophic and atrophic changes in the tubular apparatus and sclerosis of the renal tissue.
About the Authors
M. A. Akimenko
Rostov State Medical University
Russian Federation
Russian Federation
Department of Medical Biology and Genetics,
344022, Rostov-on-Don, Nahichevansky av., 29
S. S. Todorov
Rostov State Medical University
Russian Federation
Russian Federation
M.D., PhD, DMedSci, head of the morphological department and department of molecular biological and optical methods of research,
344022, Rostov-on-Don, Nahichevansky av., 29
T. S. Kolmakova
Rostov State Medical University
Russian Federation
Russian Federation
Assosiate professor, PhD, DBiolSci, Department of Medical Biology and Genetics, head,
344022, Rostov-on-Don, Nahichevansky av., 29
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Review
For citations:
Akimenko M.A., Todorov S.S., Kolmakova T.S. DYNAMICS OF MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES IN KIDNEY TISSUE DURING URETERAL OBSTRUCTION IN THE EXPERIMENT. Nephrology (Saint-Petersburg). 2017;21(5):71-75. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-5-100-108
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