DYNAMICS OF MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES IN KIDNEY TISSUE DURING URETERAL OBSTRUCTION IN THE EXPERIMENT
https://doi.org/10.24884/1561-6274-2017-21-5-100-108
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Abstract
THE AIM: the comparative study of morphological changes in kidney tissue with mechanical ureteral obstruction in the experiment at the time of 7, 14, 21 days.
Matherials and methods. The study of the dynamics of the morphological changes in the kidney showed that in the first 7 days after obstruction, there are compensatory reactions from the tubular apparatus of the medulla of the kidneys and minimal development of interstitial fibrosis.
Results. In the subsequent terms (14-21 days), compensatory phenomena in the epithelial cells of the tubules are disrupted autoregulatory mechanisms of adaptation, which is manifested in the phenomena of protein, hydrops dystrophy, atrophy, cystic transformation of epithelial cells of the tubules of the cortex and medulla layers, and the appearance of large zones of interstitial fibrosis of the stroma.
CONCLUSION. Obtained data make it possible to consider that the optimal period for performing surgical interventions, with obstructive uropathy, is the first week from the beginning of the development of the pathological process since this will prevent further development of dystrophic and atrophic changes in the tubular apparatus and sclerosis of the renal tissue.
About the Authors
M. A. Akimenko
Rostov State Medical University
Russian Federation
Russian Federation
Department of Medical Biology and Genetics,
344022, Rostov-on-Don, Nahichevansky av., 29
S. S. Todorov
Rostov State Medical University
Russian Federation
Russian Federation
M.D., PhD, DMedSci, head of the morphological department and department of molecular biological and optical methods of research,
344022, Rostov-on-Don, Nahichevansky av., 29
T. S. Kolmakova
Rostov State Medical University
Russian Federation
Russian Federation
Assosiate professor, PhD, DBiolSci, Department of Medical Biology and Genetics, head,
344022, Rostov-on-Don, Nahichevansky av., 29
References
1. Smirnov AV, Rumyantsev ASh, Dobronravov VA, Kayukov IG. XXI vek - vremya integrativnoi nefrologii. Nefrologiya 2015;19(2):22-26 [Smirnov AV, Rumyantsev AS, Dobronravov VA, Kayukov IG. XXI century - the time of integrative nephrology. Nephrology (Saint-Petersburg). 2015;19(2):22-26. (In Russ.)]
2. Truong LD, Gaber L, Eknoyan G. Obstructive uropathy. Experimental Models for Renal Diseases: Pathogenesis and Diagnosis. Contrib Nephrol 2011; 169: 311-326. https://doi.org/10.1159/000314578
3. Novikova MV, Egorova GG. Morfologicheskaya kharakteristika pochek u koshek pri gidronefroze v eksperimente. Agrarnyi vestn Urala 2010; 5 (71):64-66 [Novikova MV, Egorova GG. Morfologicheskaja harakteristika pochek u koshek pri gidronefroze v jeksperimente. Agrarnyj vestnik Urala 2010; 5 (71):64-66]
4. Akimenko MA, Sinel'nik EA, Potapov EV, Pasechnik DG. Morfologicheskie osobennosti eksperimental'noi obstruktivnoi uropatii. 3-ya itogovaya nauchnaya sessiya molodykh uchenykh RostGMU 2016;(3):77-79 [Akimenko MA, Sinelnik EA, Potapov EV, Pasechnik DG. Morfologicheskie osobennosti jeksperimental’noj obstruktivnoj uropatii. 3-ja itogovaja nauchnaja sessija molodyh uchjonyh RostGMU 2016;(3):77-79]
5. Onopko VF, Gol'dberg OA. Sravnitel'nye morfologicheskie osobennosti klinicheskogo i eksperimental'nogo gidronefroza. Meditsinskii vestnik Bashkortostana 2011; 6(2):113-116. [Onopko VF, Goldberg OA. Sravnitel’nye morfologicheskie osobennosti klinicheskogo i jeksperimental’nogo gidronefroza. Medicinskij vestnik Bashkortostana 2011; 6(2):113-116]
6. Chevalier RL. Chronic partial ureteral obstruction and the developing kidney. Pediatr Radiol 2008; 38 (1): 35-40. https://doi.org/10.1007/s00247-007-0585-z
7. Vincent IS, Okusa MD. Biology of Renal Recovery: Molecules, Mechanisms and Pathways. Nephron Clin Pract 2014; 127 (0): 10-14. https://doi.org/10.1159/000363714
8. Lima MLD, Bertti R, Moro JC et al. 99m Tc-DTPA Study to Validate an Experimental Model of Ureteral Obstruction in Rabbits: Preliminary Results. Advances in Urology 2013; 2013: pp. https://doi.org/10.1155/2013/929620
9. Yazıcı M, Celebi S, Kuzdan Ö et al. Current radiological techniques used to evaluate unilateral partial ureteral obstruction: an experimental rabbit study. International Urology and Nephrology 2015; 47(7): 1045-1050. https://doi.org/10.1007/s11255-015-0998-9
10. Li WQ, Dong ZQ, Zhou XB et al. Renovascular morphological changes in a rabbit model of hydronephrosis. Journal of Huazhong University of Science and Technology 2014; 34(4): 575-581. https://doi.org/10.1007/s11596-014-1318-9
11. Peters CA. Animal models of fetal renal disease. Prenatal Diagnosis 2001; 21(11): 917-923. https://doi.org/10.1002/pd.211
12. Berezinets OL, Rossolovskii AN, Blyumberg BI. Mekhanizmy progressirovaniya tubulointerstitsial'nykh izmenenii pri mochekamennoi bolezni. Byulleten' meditsinskikh Internet-konferentsii 2014; 4(1):87-88 [Berezinets OL, Rossolovsky AN, Blumberg BI. Mehanizmy progressirovanija tubulointersticial’nyh izmenenij pri mochekamennoj bolezni. Bjulleten’ medicinskih Internet-konferencij 2014; 4(1):87-88]
13. Chevalier RL, Forbes MS, Thornhill BA. Formation of atubular glomeruli in the developing kidney following chronic urinary tract obstruction. Pediatric Nephrology 2011; 26 (9): 1381-1385. https://doi.org/10.1007/s00467-010-1748-y
14. Giamarellos-Bourboulis EJ, Adamis T, Laoutaris G et al. Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 2004; 48 (1): 93-99. https://doi.org/10.1128/AAC.48.1.93-99.2004
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For citations:
Akimenko M.A., Todorov S.S., Kolmakova T.S. DYNAMICS OF MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES IN KIDNEY TISSUE DURING URETERAL OBSTRUCTION IN THE EXPERIMENT. Nephrology (Saint-Petersburg). 2017;21(5):71-75. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-5-100-108
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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)
ISSN 2541-9439 (Online)
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