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PLASMA LEVEL OF BITTER TASTE RECEPTORS TAS2R38 AND GLOMERULAR FILTRATION RATE IN BRONCHIAL ASTHMA

https://doi.org/10.24884/1561-6274-2018-22-1-69-74

Abstract

The aim: to investigate the  glomerular filtration  rate compared with the  plasma level of bitter  taste receptors TAS2R38  in asthma.

Patients and methods.  23 practically healthy persons and  52 patients with bronchial asthma were examined. The blood plasma TAS2R38 level was determined by an enzyme immunoassay. Glomerular filtration rate (eGFR) by CKD-EPI was estimated.

Results. There were significant differences in TAS2R38 receptor levels  between men  and  women with allergic asthma, and  in women these levels are the lowest. There was a significant decrease in eGFR in the non-allergic variant  of asthma compared with the  allergic variant  of the  disease, and  only in women this decrease reaches a statistically significant value.  When conducting a factor analysis, it was revealed that the level of bitter  taste receptors TAS2R38 is associated with an estimated glomerular filtration rate with a high negative factor load.

The conclusion. A hypothesis is advanced on the possible regulatory (protective) function of plasma (soluble) TAS2R38 receptors in relation to the corresponding membrane receptors expressed on the cells of the kidney structures (glomeruli and tubules) in bronchial asthma in women.

About the Authors

V. N. Mineev
First Saint Petersburg State Medical University
Russian Federation

Valery N. Mineev - MD, PhD, DMedSci, Prof., Department of Hospital Therapy, Research Institute of Rheumatology and Allergology, vicedirector.

197022 St. Petersburg, ul. L. Tolstoy 17, building. 10. 8(921)3596295



V. I. Trofimov
First Saint Petersburg State Medical University
Russian Federation

Vasily I. Trofimov - MD, PhD, DMedSci, Prof., Department of Hospital Therapy, Research Institute of Rheumatology and Allergology, Head Doctor of Medical Sciences.

197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7-921-913-13-28



M. A. Nyoma
First Saint Petersburg State Medical University
Russian Federation

Nyoma Mikhail Alexandrovich - MD, PhD, assistant Department of Hospital Therapy.

197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7-904-333-85-67


T. S. Vasiljeva
First Saint Petersburg State Medical University
Russian Federation

Tatiana S. Vasilieva  - MD, PhD, general practitioner polyclinic No. 34.

197022 St. Petersburg, 8(921) 359-62-95



A. A. Kuzikova
First Saint Petersburg State Medical University
Russian Federation

Anastasia A. Kuzikova – student.

197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7 981-987-05-27



References

1. Deshpande DA, Wang WC, McIlmoyle EL et al. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 2010; 16:1299–1304

2. Ekoff M, Choi JH, James A et al. Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation. J Allergy Clin Immunol 2014;134(2):475-478

3. Grassin-Delyle S, Naline E, Devillier P. Taste receptors in asthma. Curr Opin Allergy Clin Immunol 2015; 15(1):63-69

4. Минеев ВН, Кузикова АА, Нёма МА. Вкусовые рецепторы к горькому вкусу при бронхиальной астме. Мед акад журн 2017;17(2):105-110 [Mineev VN, Kuzikova AA, Nyoma MA. Vkusovy`e retceptory` k gor`komu vkusu pri bronhial`noi` astme. Med Akad Zhurn 2017;17(2):105-110]

5. Минеев ВН, Васильева ТС, Деев ДМ. Существует ли риск развития хронической болезни почек у пациентов с бронхиальной астмой? Нефрология 2017;21(4):40-47. DOI:10.24884/1561-6274-2017-21-4-40-47 [Mineev V.N., Vasiljeva T.S., Deev D.M. Is there any risk of developing chronic kidney disease in patients with bronchial asthma? Nephrology (SaintPetersburg). 2017;21(4):40-47. (In Russ.) DOI:10.24884/1561-6274-2017-21-4-40-47]

6. Liu X, Gu F, Jiang L et al. Expression of bitter taste receptor Tas2r105 in mouse kidney. Biochem Biophys Res Commun 2015; 458(4):733-738

7. Wooding SP, Atanasova S, Gunn HC et al. Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN). BMC Med Gene 2012;13:96

8. James A, Daham K, Dahlén B et al. Expression of bitter taste receptors on peripheral blood leukocytes from asthmatic patients. Am J Respir Crit Care Med 2012;185:A6752

9. Кетлинский СА, Симбирцев АС. Цитокины Фолиант, СПб., 2008; 549 с. [Ketlinskii` SA, Simbirtcev AS. Tcitokiny` Foliant, SPb., 2008; 549 s.]

10. Bagnasco D, Ferrando M, Varricchi G et al. A Critical evaluation of anti-IL-13 and anti-IL-4 strategies in severe asthma. Int Arch Allergy Immunol 2016;170(2):122-131

11. Maurer S, Wabnitz GH, Kahle NA et al. Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone. Front Immunol 2015;6:369

12. http://www.proteinatlas.org/ENSG00000257138TAS2R38/tissue/kidney

13. Heaney ML, Golde DW. Soluble receptors in human disease. J Leukoc Biol 1998; 64: 135-146

14. Reiss K, Saftig P. The «A disintegrin and metalloprotease» (ADAM) family of sheddases: Physiological and cellular functions. Semin Cell Dev Biol 2009; 20(2):126-137

15. Dreymueller D, Uhlig S, Ludwig A. ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets. Am J Physiol Lung Cell Mol Physiol 2015; 308(4):L325-343

16. Vasudevan R, Norhasniza MN, Patimah I. Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. Genet Mol Res 2011;10(2):943-947

17. Rasmussen TB, Givskov M. Quorum-sensing inhibitors as anti-pathogenic drugs. Int J Med Microbiol 2006; 296(2-3):149-161

18. Douglas JE, Cohen NA. Taste receptors mediate sinonasal immunity and respiratory disease. Int J Mol Sci 2017;18(2):437

19. Kumar R, Chhibber S, Harjai K. Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection. Kidney Int 2009;76(3):286-292

20. Tong Z, Wu X, Ovcharenko D et al. Neutrophil gelatinaseassociated lipocalin as a survival factor. Biochem J 2005;391(Pt 2):441-448

21. Schmidt-Ott KM, Mori K, Li JY et al. Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 2007; 18(2): 407-413

22. Лазарова М, Паскалев Д, Киемени Б. Таинственная сущность балканской эндемической нефропaтии. Нефрология 2007;11(2):39-44 [Lazarova M, Paskalev D, Kiemeni B. Tainstvennaia sushchnost` balkanskoi` e`ndemicheskoi` nefropatii. Nephrology (Saint-Petersburg). 2007;11(2):39-44 (In Russ.)]

23. Гиляров ДА, Сахарова ТА, Буздин АА. Молекулярные рецепторы вкусовых веществ. Биоорганическая химия 2009; 35(1):5-14 [Giliarov DA, Saharova TA, Buzdin AA. Molekuliarny`e retceptory` vkusovy`kh veshchestv. Bioorganicheskaia himiia 2009; 35(1):5-14 (In Russ.)]

24. Avau B, Depoortere I. The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity. Acta Physiol (Oxf) 2016; 216(4):407-420


Review

For citations:


Mineev V.N., Trofimov V.I., Nyoma M.A., Vasiljeva T.S., Kuzikova A.A. PLASMA LEVEL OF BITTER TASTE RECEPTORS TAS2R38 AND GLOMERULAR FILTRATION RATE IN BRONCHIAL ASTHMA. Nephrology (Saint-Petersburg). 2018;22(1):69-74. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-1-69-74

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)