PLASMA LEVEL OF BITTER TASTE RECEPTORS TAS2R38 AND GLOMERULAR FILTRATION RATE IN BRONCHIAL ASTHMA
https://doi.org/10.24884/1561-6274-2018-22-1-69-74
Abstract
The aim: to investigate the glomerular filtration rate compared with the plasma level of bitter taste receptors TAS2R38 in asthma.
Patients and methods. 23 practically healthy persons and 52 patients with bronchial asthma were examined. The blood plasma TAS2R38 level was determined by an enzyme immunoassay. Glomerular filtration rate (eGFR) by CKD-EPI was estimated.
Results. There were significant differences in TAS2R38 receptor levels between men and women with allergic asthma, and in women these levels are the lowest. There was a significant decrease in eGFR in the non-allergic variant of asthma compared with the allergic variant of the disease, and only in women this decrease reaches a statistically significant value. When conducting a factor analysis, it was revealed that the level of bitter taste receptors TAS2R38 is associated with an estimated glomerular filtration rate with a high negative factor load.
The conclusion. A hypothesis is advanced on the possible regulatory (protective) function of plasma (soluble) TAS2R38 receptors in relation to the corresponding membrane receptors expressed on the cells of the kidney structures (glomeruli and tubules) in bronchial asthma in women.
About the Authors
V. N. MineevRussian Federation
Valery N. Mineev - MD, PhD, DMedSci, Prof., Department of Hospital Therapy, Research Institute of Rheumatology and Allergology, vicedirector.
197022 St. Petersburg, ul. L. Tolstoy 17, building. 10. 8(921)3596295
V. I. Trofimov
Russian Federation
Vasily I. Trofimov - MD, PhD, DMedSci, Prof., Department of Hospital Therapy, Research Institute of Rheumatology and Allergology, Head Doctor of Medical Sciences.
197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7-921-913-13-28
M. A. Nyoma
Russian Federation
Nyoma Mikhail Alexandrovich - MD, PhD, assistant Department of Hospital Therapy.
197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7-904-333-85-67T. S. Vasiljeva
Russian Federation
Tatiana S. Vasilieva - MD, PhD, general practitioner polyclinic No. 34.
197022 St. Petersburg, 8(921) 359-62-95
A. A. Kuzikova
Russian Federation
Anastasia A. Kuzikova – student.
197022 St. Petersburg, ul. L. Tolstoy 17, building. 10, +7 981-987-05-27
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Review
For citations:
Mineev V.N., Trofimov V.I., Nyoma M.A., Vasiljeva T.S., Kuzikova A.A. PLASMA LEVEL OF BITTER TASTE RECEPTORS TAS2R38 AND GLOMERULAR FILTRATION RATE IN BRONCHIAL ASTHMA. Nephrology (Saint-Petersburg). 2018;22(1):69-74. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-1-69-74