ЧТО МЫ ЗНАЕМ И ЧЕГО НЕ ЗНАЕМ О ЗАБОЛЕВАНИЯХ ПОЧЕК У ЖЕНЩИН; ВОПРОСЫ БЕЗ ОТВЕТОВ И ОТВЕТЫ НА НЕЗАДАННЫЕ ВОПРОСЫ: РАЗМЫШЛЕНИЯ ПО ПОВОДУ ВСЕМИРНОГО ДНЯ ПОЧКИ И МЕЖДУНАРОДНОГО ЖЕНСКОГО ДНЯ

Около  10% взрослого населения планеты страдают хронической болезнью почек, которая входит  в список 20 основных причин  смерти во всем мире и ведет к пагубным последствиям как для самих пациентов, так и для членов их семей. Всемирный День  Почки в 2018  году совпадает с Международным женским днем, что дает нам повод задуматься об  особой важности состояния здоровья женщин, и в особенности о «почечном здоровье», для  ныне  живущей популяции и для будущих  поколений. Нам представляется не только уникальная возможность узнать как можно больше об  особенностях заболеваний почек  у женщин, но и шире использовать полученные знания. Женщины, девушки и девочки в целом составляют примерно 50%  населения мира и вносят огромный вклад в жизнь  общества, не говоря уже о важнейшей роли  в семейной жизни. Вместе с тем,  гендерные различия в доступе к образованию, медицинской помощи и участии в клинических исследованиях все  еще существуют практически повсеместно. Беременность, представляющая особую нагрузку на организм женщины, и нередко оказывающаяся поводом для  выявления уже существующих заболевания почек, может также  приводить к манифестации острых и хронических почечных  заболеваний, которые, в свою очередь, могут сказываться на потомстве – в том числе и на состоянии почек. Многие аутоиммунные и другие заболевания чаще развиваются у женщин, чем у мужчин, и неблагоприятно сказываются на способности к деторождению и на состоянии плода. Осложнения диализа у женщин отличаются от осложнений у мужчин и, кроме того, женщины с большей вероятностью оказываются донорами, нежели реципиентами почечного трансплантата. В этой передовой статье мы сконцентрировали внимание на том,  что мы знаем и чего мы не знаем о «почечном здоровье» и заболеваниях почек у женщин, и на том,  что мы можем и должны узнать в будущем для улучшения исходов заболеваний почек во всем мире.

1. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388(10053):1545–1602. doi: 10.1016/S0140-6736(16)31678-6

2. von Dadelszen P, Payne B, Li J et al. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the full PIERS model. Lancet 2011; 377(9761):219–227. doi: 10.1016/S0140-6736(10)61351-7

3. Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, et al. Pre-eclampsia. Lancet 2016; 387(10022):999–1011. doi: 10.1016/S0140-6736(15)00070-7

4. Vikse BE, Irgens LM, Leivestad T et al. Preeclampsia and the risk of end-stage renal disease. N Engl J Med 2008;359(8):800–809. doi: 10.1056/NEJMoa0706790

5. Theilen LH, Fraser A, Hollingshaus MS et al. All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy. Obstet Gynecol 2016;128(2):238–244

6. Piccoli GB, Cabiddu G, Attini R et al. Risk of Adverse Pregnancy Outcomes in Women with CKD. J Am Soc Nephrol 2015;26(8):2011–2022. doi: 10.1681/ASN.2014050459

7. Zhang J-J, Ma X-X, Hao L et al. A Systematic Review and Meta-Analysis of Outcomes of Pregnancy in CKD and CKD Outcomes in Pregnancy. Clin J Am Soc Nephrol 2015;10(11):1964–1978. doi: 10.2215/CJN.09250914

8. Alkhunaizi A, Melamed N, Hladunewich MA. Pregnancy in advanced chronic kidney disease and end-stage renal disease. Curr Opin Nephrol Hypertens 2015;24(3):252–259. doi: 10.1097/MNH.0000000000000119

9. Piccoli GB, Cabiddu G, Castellino S et al. A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy. J Nephrol 2017;30(3):307–317. doi: 10.1007/s40620-017-0390-1

10. Liu Y, Ma X, Zheng J, Liu X, Yan T. Pregnancy outcomes in patients with acute kidney injury during pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2017;17(1):235. doi: 10.1186/s12884-017-1402-9

11. Jim B, Garovic VD. Acute Kidney Injury in Pregnancy. Semin Nephrol 2017; 37(4):378–385. doi: 10.1016/j. semnephrol.2017.05.010

12. Acharya A. Management of Acute Kidney Injury in Pregnancy for the Obstetrician. Obstet Gynecol Clin North Am 2016 Dec;43(4):747–765. doi: 10.1016/j.ogc.2016.07.007

13. Iseki K. Gender differences in chronic kidney disease. Kidney International 2008;74(4):415–417. doi: 10.1038/ki.2008.261

14. Nitsch D, Grams M, Sang Y et al. Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ 2013;346:f324. doi: 10.1136/bmj.f324

15. Levin A, Djurdjev O, Beaulieu M, Er L. Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort. Am J Kidney Dis 2008;52(4):661–671. doi: 10.1053/j.ajkd.2008.06.023

16. Weiner DE, Tighiouart H, Elsayed EF et al. The Framingham predictive instrument in chronic kidney disease. J Am Coll Cardiol 2007;50(3):217–224. doi: 10.1016/j.jacc.2007.03.037

17. Oladapo OT, Adetoro OO, Ekele BA et al. When getting there is not enough: a nationwide cross-sectional study of 998 maternal deaths and 1451 near-misses in public tertiary hospitals in a low-income country. BJOG 2016;123(6):928–938. doi:10.1111/1471-0528.13450

18. Tranquilli AL, Dekker G, Magee L et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Pregnancy Hypertens 2014;4(2):97–104. doi:10.1016/j.preghy.2014.02.001

19. Liu Y, Bao H, Jiang Z et al. Pregnancy-related Acute Kidney Injury and a Review of the Literature in China. Intern Med 2015;54(14):1695–1703. doi: 10.2169/ internalmedicine.54.3870

20. Prakash J, Pant P, Prakash S et al. Changing picture of acute kidney injury in pregnancy: Study of 259 cases over a period of 33 years. Indian J Nephrol 2016;26(4):262–267. doi: 10.4103/0971-4065.161018

21. Ibarra-Hernández M, Orozco-Guillén OA, de la AlcantarVallín ML et al. Acute kidney injury in pregnancy and the role of underlying CKD: a point of view from México. J Nephrol 2017;30(6):773–780. doi: 10.1007/s40620-017-0444-4

22. Blázquez A, García D, Rodríguez A et al. Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis. J Assist Reprod Genet 2016 Jul;33(7):855–863. doi: 10.1007/s10815-016-0701-9

23. O’Gorman N, Wright D, Poon LC et al. Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol 2017;49(6):756–760. doi: 10.1002/uog.17455

24. Zeisler H, Llurba E, Chantraine F et al. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia. N Engl J Med 2016;374(1):13-22. doi: 10.1056/NEJMoa1414838

25. 25. Garovic VD. The Role of the Podocyte in Preeclampsia. Clin J Am Soc Nephrol 2014;9(8):1337–1340. doi: 10.2215/CJN.05940614

26. Wide-Swensson D, Strevens H, Willner J. Antepartum percutaneous renal biopsy. Int J Gynaecol Obstet 2007;98(2):88–92. doi: 10.1016/j.ijgo.2007.03.049

27. Shiiki H, Dohi K, Hanatani M et al. Focal and segmental glomerulosclerosis in preeclamptic patients with nephrotic syndrome. Am J Nephrol 1990;10(3):205–212. PMID: 2382682

28. Linsell L, Malouf R, Morris J. et al. Risk Factor Models for Neurodevelopmental Outcomes in Children Born Very Preterm or With Very Low Birth Weight: A Systematic Review of Methodology and Reporting. Am J Epidemiol 2017;185(7):601–612. doi: 10.1093/aje/kww135

29. Guellec I, Lapillonne A, Marret S et al. Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants. J Pediatr 2016;175:93–99.e1. doi: 10.1016/j.jpeds.2016.05.027

30. Moore T, Hennessy EM, Myles J et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ 2012;345:e7961. doi: 10.1136/bmj.e7961

31. Guillén Ú, DeMauro S, Ma L et al. Relationship Between Attrition and Neurodevelopmental Impairment Rates in Extremely Preterm Infants at 18 to 24 Months: A Systematic Review. Arch Pediatr Adolesc Med 2012;166(2):178–184. doi: 10.1001/archpediatrics.2011.616

32. Ranke MB, Schweizer R, Rodemann SM et al. Schoolchildren born VLBW or VLGA show height-related changes in body composition and muscle function but no evidence of metabolic syndrome risk factors. Results from the NEOLONG study. J Pediatr Endocrinol Metab 2016;29(2):163–172. doi: 10.1515/jpem-2015-0266

33. Castanys-Muñoz E, Kennedy K, Castañeda-Gutiérrez E et al. Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatr 2017;106(8):1230–1238. doi: 10.1111/apa.13868

34. Ong KK, Kennedy K, Castañeda-Gutiérrez E et al. Postnatal growth in preterm infants and later health outcomes: a systematic review. Acta Paediatr 2015;104(10):974–986. doi: 10.1111/apa.13128

35. Low Birth Weight and Nephron Number Working Group. The Impact of Kidney Development on the Life Course: A Consensus Document for Action. Nephron 2017;136(1):3–49. doi: 10.1159/000457967

36. Luyckx VA, Bertram JF, Brenner BM et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet 2013;382(9888):273–283. doi: 10.1016/S0140-6736(13)60311-6

37. Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes--a global concern. Nat Rev Nephrol 2015;11(3):135–149. doi: 10.1038/nrneph.2014.251

38. Davison JM, Lindheimer MD. Pregnancy and chronic kidney disease. Semin Nephrol 2011;31(1):86–99. doi: 10.1016/j.semnephrol.2010.10.008

39. Hall M. Pregnancy in Women with CKD: A Success Story. Am J Kidney Dis 2016;68(4):633–639. doi: 10.1053/j. ajkd.2016.04.022

40. Nevis IF, Reitsma A, Dominic A et al. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol 201;6(11):2587–2598. doi: 10.2215/CJN.10841210

41. Cabiddu G, Castellino S, Gernone G et al. A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy. J Nephrol 2016;29(3):277–303. doi: 10.1007/s40620-016-0285-6

42. Garg AX, Nevis IF, McArthur E et al. Gestational hypertension and preeclampsia in living kidney donors. N Engl J Med 2015;372(2):124–133. doi: 10.1056/NEJMoa1408932

43. Josephson MA. Transplantation: pregnancy after kidney donation: more questions than answers. Nat Rev Nephrol 2009;5(9):495–497. doi: 10.1038/nrneph.2009.129

44. Gianfreda D, Quaglini S, Frontini G et al. Does pregnancy have any impact on long term damage accrual and on the outcome of lupus nephritis? J Autoimmun 2017;84:46–54. doi: 10.1016/j. jaut.2017.06.003

45. Blom K, Odutayo A, Bramham K, Hladunewich MA. Pregnancy and Glomerular Disease: A Systematic Review of the Literature with Management Guidelines. Сlin J Am Soc Nephrol 2017;12(11):1862-1872. doi: 10.2215/CJN.00130117

46. Imbasciati E, Gregorini G, Cabiddu G et al. Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis 2007;49(6):753–762. doi: 10.1053/j.ajkd.2007.03.022

47. Fischer MJ. Chronic kidney disease and pregnancy: maternal and fetal outcomes. Adv Chronic Kidney Dis 2007;14(2):132– 145. doi: 10.1053/j.ackd.2007.01.004

48. Bramham K. Diabetic Nephropathy and Pregnancy. Semin Nephrol 2017;37(4):362–369. doi: 10.1016/j. semnephrol.2017.05.008

49. Eswarappa M, Rakesh M, Sonika P et al. Spectrum of renal injury in pregnancy-induced hypertension: Experience from a single center in India. Saudi Journal of Kidney Diseases and Transplantation 2017;28(2):279. DOI: 10.4103/1319-2442.202790

50. Prakash J. The kidney in pregnancy: A journey of three decades. Indian J Nephrol 2012;22(3):159–167. doi: 10.4103/0971-4065.98750

51. Piccoli GB, Fassio F, Attini R et al. Pregnancy in CKD: whom should we follow and why? Nephrol Dial Transplant 2012;27 Suppl 3:iii111–118. doi: 10.1093/ndt/gfs302

52. Piccoli GB, Cabiddu G, Daidone G et al. The children of dialysis: live-born babies from on-dialysis mothers in Italy – an epidemiological perspective comparing dialysis, kidney transplantation and the overall population. Nephrol Dial Transplant 2014;29(8):1578–1586. doi: 10.1093/ndt/gfu092

53. Jesudason S, Grace BS, McDonald SP. Pregnancy Outcomes According to Dialysis Commencing Before or After Conception in Women with ESRD. Clin J Am Soc Nephrol 2014;9(1):143–149. doi: 10.2215/CJN.03560413

54. Hladunewich MA, Hou S, Odutayo A et al. Intensive hemodialysis associates with improved pregnancy outcomes: a Canadian and United States cohort comparison. J Am Soc Nephrol 2014;25(5):1103–1109. doi:10.1681/ASN.2013080825

55. Piccoli GB, Minelli F, Versino E et al. Pregnancy in dialysis patients in the new millennium: a systematic review and metaregression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant 2016;31(11):1915–1934. doi: 10.1093/ndt/gfv395

56. Deshpande NA, James NT, Kucirka LM et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant 2011;11(11):2388–2404. doi: 10.1111/j.1600-6143.2011.03656.x

57. Deshpande NA, Coscia LA, Gomez-Lobo V et al. Pregnancy after solid organ transplantation: a guide for obstetric management. Rev Obstet Gynecol 2013;6(3–4):116–125. PMC4002187

58. Bramham K, Nelson-Piercy C, Gao H et al. Pregnancy in renal transplant recipients: a UK national cohort study. Clin J Am Soc Nephrol 2013;8(2):290–298. doi: 10.2215/CJN.06170612

59. Piccoli GB, Cabiddu G, Attini R et al. Outcomes of Pregnancies After Kidney Transplantation: Lessons Learned from CKD. A Comparison of Transplanted, Nontransplanted Chronic Kidney Disease Patients and Low-Risk Pregnancies: A Multicenter Nationwide Analysis. Transplantation 2017;101(10):2536–2544. doi: 10.1097/TP.0000000000001649

60. Webster P, Lightstone L, McKay DB, Josephson MA. Pregnancy in chronic kidney disease and kidney transplantation. Kidney Int 2017; 91(5):1047–1056. doi:10.1016/j.kint.2016.10.045

61. Pietrzak B, Mazanowska N, Kociszewska-Najman B et al. Successful Pregnancy Outcome after In Vitro Fertilization in a Kidney Graft Recipient: A Case Report and Literature Review. Ann Transplant 2015;20:338–341. doi: 10.12659/AOT.893735

62. Norrman E, Bergh C, Wennerholm U-B. Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Hum Reprod 2015;30(1):205–213. doi: 10.1093/humrep/deu293

63. Tedeschi SK, Bermas B, Costenbader KH. Sexual disparities in the incidence and course of SLE and RA. Clin Immunol 2013;149(2):211–218. doi: 10.1016/j.clim.2013.03.003

64. Marder W, Vinet É, Somers EC. Rheumatic autoimmune diseases in women and midlife health. Womens Midlife Health [Internet] 2015 [cited 2017 Oct 19];1. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC5444314/

65. Ortona E, Pierdominici M, Maselli A. et al. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita 2016;52(2):205–212. doi: 10.4415/ANN_16_02_12

66. Petri M. Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol 2002;16(5):847–858. PMID: 12473278

67. Weckerle CE, Niewold TB. The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies. Clin Rev Allergy Immunol 2011;40(1):42–49. doi:10.1007/s12016-009-8192-4

68. Scofield RH, Bruner GR, Namjou B et al. Klinefelter’s syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 2008;58(8):2511–2517. doi: 10.1002/art.23701

69. Pierdominici M and Ortona E. Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus. Int Trends in Immun 2013;1(2):24–34

70. Maselli A, Conti F, Alessandri C et al. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus. Biol Sex Differ [Internet] 2016 [cited 2017 Oct 19];7. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4709986/

71. Kim SJ, Schätzle S, Ahmed SS et al. Increased cathepsin S in Prdm1(-/-) dendritic cells alters the TFH cell repertoire and contributes to lupus. Nat Immunol 2017;18(9):1016–1024. doi: 10.1038/ni.3793

72. Langefeld CD, Ainsworth HC, Cunninghame Graham DS et al. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 2017;8:16021. doi: 10.1038/ ncomms16021

73. Niewold TB, Hua J, Lehman TJA et al. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007;8(6):492–502. doi: 10.1038/sj.gene.6364408

74. Tower C, Mathen S, Crocker I, Bruce IN. Regulatory T cells in Systemic Lupus Erythematosus and Pregnancy. Am J Reprod Immunol 2013;69(6):588–595. doi: 10.1111/aji.12081

75. 75. Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. CJASN 2016;CJN.05780616. doi: 10.2215/CJN.05780616

76. Buyon JP, Kim MY, Guerra MM et al. Kidney Outcomes and Risk Factors for Nephritis (Flare/De Novo) in a Multiethnic Cohort of Pregnant Patients with Lupus. Clin J Am Soc Nephrol 2017;12(6):940–946. doi: 10.2215/CJN.11431116

77. Yelin E, Yazdany J, Trupin L. Relationship Between Process of Care and a Subsequent Increase in Damage in Systemic Lupus Erythematosus. Arthritis Care & Research 2017;69(6):927–932. doi: 10.1002/acr.22977

78. Kaplowitz ET, Ferguson S, Guerra M et al. Socioeconomic Status Contributes to Racial/Ethnic Disparities in Adverse Pregnancy Outcomes among Women with Systemic Lupus Erythematosus. Arthritis Care Res 2017; 69 (6):833–841. doi: 10.1002/acr.23021

79. Myasoedova E, Crowson CS, Kremers HM et al. Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007. Arthritis Rheum 2010;62(6):1576–1582. doi: 10.1002/art.27425

80. Goemaere S, Ackerman C, Goethals K et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol 1990;17(12):1620–1622 PMID: 2084234

81. de Man YA, Dolhain RJEM, van de Geijn FE et al. Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum 2008;59(9):1241–1248

82. Icardi A, Araghi P, Ciabattoni M et al. Kidney involvement in rheumatoid arthritis. Reumatismo 2003;55(2):76–85. PMID: 12874640

83. Anders H-J, Vielhauer V. Renal co-morbidity in patients with rheumatic diseases. Arthritis Research & Therapy 201;13:222. doi: 10.1186/ar3256

84. Chiu H-Y, Huang H-L, Li C-H et al. Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications – A National Population-Based Cohort Study. PLOS ONE 2015;10(9):e0136508. doi: 10.1371/journal.pone.0153431

85. Vinet É, Bernatsky S, Hudson M et al. Effect of menopause on the modified Rodnan skin score in systemic sclerosis. Arthritis Research & Therapy 2014;16:R130. doi: 10.1186/ar4587

86. Sammaritano LR. Menopause in patients with autoimmune diseases. Autoimmun Rev 2012;11(6–7):A430–436. doi: 10.1016/j.autrev.2011.11.006

87. Penn H, Denton CP. Diagnosis, management and prevention of scleroderma renal disease. Curr Opin Rheumatol 2008;20(6):692–696. doi: 10.1097/BOR.0b013e3283108df7

88. Anders HJ, Wiebecke B, Haedecke C et al. MPO-ANCAPositive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease? Am J Kidney Dis 1999;33(4):e3. PMID: 10196034

89. Zakharova EV, Makarova TA, Stolyarevich ES. ANCAAssociated Vasculitis in Patient with CREST-Syndrome – Case Report [Internet]. [cited 2017 Oct 19]. Available from: https://www. eertechz.com/Clinical-Nephrology/ACN-2-115.php

90. Eckardt K-U, Coresh J, Devuyst O et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 2013;382(9887):158–169. doi: 10.1016/S01406736(13)60439-0

91. Saran R, Robinson B, Abbott KC et al. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis 2017;69(3 Suppl 1):A7–8. doi: 10.1053/j.ajkd.2016.12.004

92. Liyanage T, Ninomiya T, Jha V et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 2015;385(9981):1975–1982. doi: 10.1016/S0140-6736-(14)61601-9

93. Ojo A. Addressing the global burden of chronic kidney disease through clinical and translational research. Trans Am Clin Climatol Assoc 2014;125:229–243; discussion 243-246

94. WHO. Addressing gender within primary health care reforms. In: WHO editor. Gender, women and primary health care renewal: a discussion paper [Internet]. [cited 2017 Oct 19]. Available from: http://apps.who.int/iris/bitstream/10665/44430/1/9789241564038_eng.pdf

95. Eguavoen ANT, Odiagbe SO, Obetoh GI. The Status of Women, Sex Preference, Decision-Making and Fertility Control in Ekpoma Community of Nigeria. J Soc Sci 2007; 15(1):43–49

96. Halle MP, Takongue C, Kengne AP et al. Epidemiological profile of patients with end stage renal disease in a referral hospital in Cameroon. BMC Nephrol 2015;16:59. doi: 10.1186/s12882-015-0044-2

97. Ajayi S, Raji Y, Bello T et al. Unaffordability of renal replacement therapy in Nigeria. Hong Kong Journal of Nephrology 2016;18:15–29

98. Kausz AT, Obrador GT, Arora P et al. Late initiation of dialysis among women and ethnic minorities in the United States. J Am Soc Nephrol 2000;11(12):2351–2357. PMID: 11095658

99. Coresh J, Byrd-Holt D, Astor BC et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol 2005;16(1):180–188. doi: 10.1681/ASN.2004070539

100. Adams SV, Rivara M, Streja E et al. Sex Differences in Hospitalizations with Maintenance Hemodialysis. J Am Soc Nephrol 2017;28(9):2721–2728. doi: 10.1681/ASN.2016090986

101. Ethier J, Mendelssohn DC, Elder SJ et al. Vascular access use and outcomes: an international perspective from the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant 2008;23(10):3219–3226. doi: 10.1093/ndt/gfn261

102. Depner TA. Prescribing Hemodialysis: The Role of Gender. Adv Ren Replace Ther 2003 Jan;10(1):71-77. doi: 10.1053/jarr.2003.50007

103. Sehgal AR. Outcomes of renal replacement therapy among blacks and women. Am J Kidney Dis 2000;35(4):S148–152. PMID: 10766013

104. Jindal RM, Ryan JJ, Sajjad I et al. Kidney transplantation and gender disparity. Am J Nephrol 2005;25(5):474–483. doi: 10.1159/000087920

105. Couchoud C, Bayat S, Villar E et al. REIN registry. A new approach for measuring gender disparity in access to renal transplantation waiting lists. Transplantation 2012; 94(5):513–519

106. Liu G, Li X, Liu T et al. Gender disparity of living donor renal transplantation in East China. Clin Transplant 2013;27(1):98–103. doi: 10.1111/ctr.12003

107. Naghibi O, Naghibi M, Nazemian F. Gender disparity in kidney transplantation. Saudi J Kidney Dis Transpl 2008;19(4):545– 550. PMID: 18580010

108. Bal MM, Saikia B. Gender bias in renal transplantation: are women alone donating kidneys in India? Transplant Proc 2007; 39(10):2961–2963. DOI: 10.1016/j.transproceed.2007.08.089

109. Hogan J, Couchoud C, Bonthuis M et al. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data from the ESPN/ERA-EDTA Registry. Am J Transplant 2016;16(7):2097–2105. doi: 10.1111/ajt.13723

110. Gillespie A, Hammer H, Kolenikov S et al. Sex Differences and Attitudes toward Living Donor Kidney Transplantation among Urban Black Patients on Hemodialysis. Clin J Am Soc Nephrol 2014;9(10):1764–1772. doi: 10.2215/CJN.12531213

111. Salter ML, McAdams-Demarco MA, Law A et al. Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 2014;62(5):843–849. doi: 10.1111/jgs.12801

112. Piccoli GB, Attini R, Cabiddu G et al. Maternal-fetal outcomes in pregnant women with glomerulonephritides. Are all glomerulonephritides alike in pregnancy? J Autoimmun 2017; 79: 91–98. doi: 10.1016/j.jaut.2017.01.008

113. Seeger H, Salfeld P, Eisel R et al. Complicated pregnancies in inherited distal renal tubular acidosis: importance of acid-base balance. J Nephrol 2017;30(3):455–460. doi: 10.1007/s40620-016-0370-x

114. Yefet E, Tovbin D, Nachum Z. Pregnancy outcomes in patients with Alport syndrome. Arch Gynecol Obstet 2016; 293(4):739–747. doi: 10.1007/s00404-015-3893-9