WHAT WE DO AND DO NOT KNOW ABOUT WOMEN AND KIDNEY DISEASES; QUESTIONS UNANSWERED AND ANSWERS UNQUESTIONED: REFLECTION ON WORLD KIDNEY DAY AND INTERNATIONALWOMAN’S DAY
https://doi.org/10.24884/1561-6274-2018-22-2-12-25
Abstract
Chronic Kidney Disease affects approximately 10% of the world’s adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women’s Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women’s health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% of the world’s population, are important contributors to society and their families. Gender differences continue to exist around the world in access to education, medical care, and participation in clinical studies. Pregnancy is a unique state for women, offering an opportunity for diagnosis of kidney disease, but also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to impact women with profound consequences for child bearing, and on the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants. In this editorial, we focus on what we do and do not know about women, kidney health, and kidney disease, and what we might learn in the future to improve outcomes worldwide.
About the Authors
Giorgina B. PiccoliItaly
Department of Clinical and Biological Sciences,University of Torino,Italy;
Nephrology, Centre Hospitalier Le Mans, Le Mans, FranceMona Alrukhaimi
United Arab Emirates
Departmentof Medicine
Dubai
Zhi-Hong Liu
China
Nanjing
Elena Zakharova
Russian Federation
Nephrology
Moscow
Adeera Levin
Canada
Department of Medicine, Division of Nephrology
Vancouver, British ColumbiaReferences
1. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388(10053):1545–1602. doi: 10.1016/S0140-6736(16)31678-6
2. von Dadelszen P, Payne B, Li J et al. Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the full PIERS model. Lancet 2011; 377(9761):219–227. doi: 10.1016/S0140-6736(10)61351-7
3. Mol BWJ, Roberts CT, Thangaratinam S, Magee LA, et al. Pre-eclampsia. Lancet 2016; 387(10022):999–1011. doi: 10.1016/S0140-6736(15)00070-7
4. Vikse BE, Irgens LM, Leivestad T et al. Preeclampsia and the risk of end-stage renal disease. N Engl J Med 2008;359(8):800–809. doi: 10.1056/NEJMoa0706790
5. Theilen LH, Fraser A, Hollingshaus MS et al. All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy. Obstet Gynecol 2016;128(2):238–244
6. Piccoli GB, Cabiddu G, Attini R et al. Risk of Adverse Pregnancy Outcomes in Women with CKD. J Am Soc Nephrol 2015;26(8):2011–2022. doi: 10.1681/ASN.2014050459
7. Zhang J-J, Ma X-X, Hao L et al. A Systematic Review and Meta-Analysis of Outcomes of Pregnancy in CKD and CKD Outcomes in Pregnancy. Clin J Am Soc Nephrol 2015;10(11):1964–1978. doi: 10.2215/CJN.09250914
8. Alkhunaizi A, Melamed N, Hladunewich MA. Pregnancy in advanced chronic kidney disease and end-stage renal disease. Curr Opin Nephrol Hypertens 2015;24(3):252–259. doi: 10.1097/MNH.0000000000000119
9. Piccoli GB, Cabiddu G, Castellino S et al. A best practice position statement on the role of the nephrologist in the prevention and follow-up of preeclampsia: the Italian study group on kidney and pregnancy. J Nephrol 2017;30(3):307–317. doi: 10.1007/s40620-017-0390-1
10. Liu Y, Ma X, Zheng J, Liu X, Yan T. Pregnancy outcomes in patients with acute kidney injury during pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth 2017;17(1):235. doi: 10.1186/s12884-017-1402-9
11. Jim B, Garovic VD. Acute Kidney Injury in Pregnancy. Semin Nephrol 2017; 37(4):378–385. doi: 10.1016/j. semnephrol.2017.05.010
12. Acharya A. Management of Acute Kidney Injury in Pregnancy for the Obstetrician. Obstet Gynecol Clin North Am 2016 Dec;43(4):747–765. doi: 10.1016/j.ogc.2016.07.007
13. Iseki K. Gender differences in chronic kidney disease. Kidney International 2008;74(4):415–417. doi: 10.1038/ki.2008.261
14. Nitsch D, Grams M, Sang Y et al. Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ 2013;346:f324. doi: 10.1136/bmj.f324
15. Levin A, Djurdjev O, Beaulieu M, Er L. Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort. Am J Kidney Dis 2008;52(4):661–671. doi: 10.1053/j.ajkd.2008.06.023
16. Weiner DE, Tighiouart H, Elsayed EF et al. The Framingham predictive instrument in chronic kidney disease. J Am Coll Cardiol 2007;50(3):217–224. doi: 10.1016/j.jacc.2007.03.037
17. Oladapo OT, Adetoro OO, Ekele BA et al. When getting there is not enough: a nationwide cross-sectional study of 998 maternal deaths and 1451 near-misses in public tertiary hospitals in a low-income country. BJOG 2016;123(6):928–938. doi:10.1111/1471-0528.13450
18. Tranquilli AL, Dekker G, Magee L et al. The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Pregnancy Hypertens 2014;4(2):97–104. doi:10.1016/j.preghy.2014.02.001
19. Liu Y, Bao H, Jiang Z et al. Pregnancy-related Acute Kidney Injury and a Review of the Literature in China. Intern Med 2015;54(14):1695–1703. doi: 10.2169/ internalmedicine.54.3870
20. Prakash J, Pant P, Prakash S et al. Changing picture of acute kidney injury in pregnancy: Study of 259 cases over a period of 33 years. Indian J Nephrol 2016;26(4):262–267. doi: 10.4103/0971-4065.161018
21. Ibarra-Hernández M, Orozco-Guillén OA, de la AlcantarVallín ML et al. Acute kidney injury in pregnancy and the role of underlying CKD: a point of view from México. J Nephrol 2017;30(6):773–780. doi: 10.1007/s40620-017-0444-4
22. Blázquez A, García D, Rodríguez A et al. Is oocyte donation a risk factor for preeclampsia? A systematic review and meta-analysis. J Assist Reprod Genet 2016 Jul;33(7):855–863. doi: 10.1007/s10815-016-0701-9
23. O’Gorman N, Wright D, Poon LC et al. Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol 2017;49(6):756–760. doi: 10.1002/uog.17455
24. Zeisler H, Llurba E, Chantraine F et al. Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia. N Engl J Med 2016;374(1):13-22. doi: 10.1056/NEJMoa1414838
25. 25. Garovic VD. The Role of the Podocyte in Preeclampsia. Clin J Am Soc Nephrol 2014;9(8):1337–1340. doi: 10.2215/CJN.05940614
26. Wide-Swensson D, Strevens H, Willner J. Antepartum percutaneous renal biopsy. Int J Gynaecol Obstet 2007;98(2):88–92. doi: 10.1016/j.ijgo.2007.03.049
27. Shiiki H, Dohi K, Hanatani M et al. Focal and segmental glomerulosclerosis in preeclamptic patients with nephrotic syndrome. Am J Nephrol 1990;10(3):205–212. PMID: 2382682
28. Linsell L, Malouf R, Morris J. et al. Risk Factor Models for Neurodevelopmental Outcomes in Children Born Very Preterm or With Very Low Birth Weight: A Systematic Review of Methodology and Reporting. Am J Epidemiol 2017;185(7):601–612. doi: 10.1093/aje/kww135
29. Guellec I, Lapillonne A, Marret S et al. Effect of Intra- and Extrauterine Growth on Long-Term Neurologic Outcomes of Very Preterm Infants. J Pediatr 2016;175:93–99.e1. doi: 10.1016/j.jpeds.2016.05.027
30. Moore T, Hennessy EM, Myles J et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ 2012;345:e7961. doi: 10.1136/bmj.e7961
31. Guillén Ú, DeMauro S, Ma L et al. Relationship Between Attrition and Neurodevelopmental Impairment Rates in Extremely Preterm Infants at 18 to 24 Months: A Systematic Review. Arch Pediatr Adolesc Med 2012;166(2):178–184. doi: 10.1001/archpediatrics.2011.616
32. Ranke MB, Schweizer R, Rodemann SM et al. Schoolchildren born VLBW or VLGA show height-related changes in body composition and muscle function but no evidence of metabolic syndrome risk factors. Results from the NEOLONG study. J Pediatr Endocrinol Metab 2016;29(2):163–172. doi: 10.1515/jpem-2015-0266
33. Castanys-Muñoz E, Kennedy K, Castañeda-Gutiérrez E et al. Systematic review indicates postnatal growth in term infants born small-for-gestational-age being associated with later neurocognitive and metabolic outcomes. Acta Paediatr 2017;106(8):1230–1238. doi: 10.1111/apa.13868
34. Ong KK, Kennedy K, Castañeda-Gutiérrez E et al. Postnatal growth in preterm infants and later health outcomes: a systematic review. Acta Paediatr 2015;104(10):974–986. doi: 10.1111/apa.13128
35. Low Birth Weight and Nephron Number Working Group. The Impact of Kidney Development on the Life Course: A Consensus Document for Action. Nephron 2017;136(1):3–49. doi: 10.1159/000457967
36. Luyckx VA, Bertram JF, Brenner BM et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet 2013;382(9888):273–283. doi: 10.1016/S0140-6736(13)60311-6
37. Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes--a global concern. Nat Rev Nephrol 2015;11(3):135–149. doi: 10.1038/nrneph.2014.251
38. Davison JM, Lindheimer MD. Pregnancy and chronic kidney disease. Semin Nephrol 2011;31(1):86–99. doi: 10.1016/j.semnephrol.2010.10.008
39. Hall M. Pregnancy in Women with CKD: A Success Story. Am J Kidney Dis 2016;68(4):633–639. doi: 10.1053/j. ajkd.2016.04.022
40. Nevis IF, Reitsma A, Dominic A et al. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol 201;6(11):2587–2598. doi: 10.2215/CJN.10841210
41. Cabiddu G, Castellino S, Gernone G et al. A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy. J Nephrol 2016;29(3):277–303. doi: 10.1007/s40620-016-0285-6
42. Garg AX, Nevis IF, McArthur E et al. Gestational hypertension and preeclampsia in living kidney donors. N Engl J Med 2015;372(2):124–133. doi: 10.1056/NEJMoa1408932
43. Josephson MA. Transplantation: pregnancy after kidney donation: more questions than answers. Nat Rev Nephrol 2009;5(9):495–497. doi: 10.1038/nrneph.2009.129
44. Gianfreda D, Quaglini S, Frontini G et al. Does pregnancy have any impact on long term damage accrual and on the outcome of lupus nephritis? J Autoimmun 2017;84:46–54. doi: 10.1016/j. jaut.2017.06.003
45. Blom K, Odutayo A, Bramham K, Hladunewich MA. Pregnancy and Glomerular Disease: A Systematic Review of the Literature with Management Guidelines. Сlin J Am Soc Nephrol 2017;12(11):1862-1872. doi: 10.2215/CJN.00130117
46. Imbasciati E, Gregorini G, Cabiddu G et al. Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis 2007;49(6):753–762. doi: 10.1053/j.ajkd.2007.03.022
47. Fischer MJ. Chronic kidney disease and pregnancy: maternal and fetal outcomes. Adv Chronic Kidney Dis 2007;14(2):132– 145. doi: 10.1053/j.ackd.2007.01.004
48. Bramham K. Diabetic Nephropathy and Pregnancy. Semin Nephrol 2017;37(4):362–369. doi: 10.1016/j. semnephrol.2017.05.008
49. Eswarappa M, Rakesh M, Sonika P et al. Spectrum of renal injury in pregnancy-induced hypertension: Experience from a single center in India. Saudi Journal of Kidney Diseases and Transplantation 2017;28(2):279. DOI: 10.4103/1319-2442.202790
50. Prakash J. The kidney in pregnancy: A journey of three decades. Indian J Nephrol 2012;22(3):159–167. doi: 10.4103/0971-4065.98750
51. Piccoli GB, Fassio F, Attini R et al. Pregnancy in CKD: whom should we follow and why? Nephrol Dial Transplant 2012;27 Suppl 3:iii111–118. doi: 10.1093/ndt/gfs302
52. Piccoli GB, Cabiddu G, Daidone G et al. The children of dialysis: live-born babies from on-dialysis mothers in Italy – an epidemiological perspective comparing dialysis, kidney transplantation and the overall population. Nephrol Dial Transplant 2014;29(8):1578–1586. doi: 10.1093/ndt/gfu092
53. Jesudason S, Grace BS, McDonald SP. Pregnancy Outcomes According to Dialysis Commencing Before or After Conception in Women with ESRD. Clin J Am Soc Nephrol 2014;9(1):143–149. doi: 10.2215/CJN.03560413
54. Hladunewich MA, Hou S, Odutayo A et al. Intensive hemodialysis associates with improved pregnancy outcomes: a Canadian and United States cohort comparison. J Am Soc Nephrol 2014;25(5):1103–1109. doi:10.1681/ASN.2013080825
55. Piccoli GB, Minelli F, Versino E et al. Pregnancy in dialysis patients in the new millennium: a systematic review and metaregression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant 2016;31(11):1915–1934. doi: 10.1093/ndt/gfv395
56. Deshpande NA, James NT, Kucirka LM et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant 2011;11(11):2388–2404. doi: 10.1111/j.1600-6143.2011.03656.x
57. Deshpande NA, Coscia LA, Gomez-Lobo V et al. Pregnancy after solid organ transplantation: a guide for obstetric management. Rev Obstet Gynecol 2013;6(3–4):116–125. PMC4002187
58. Bramham K, Nelson-Piercy C, Gao H et al. Pregnancy in renal transplant recipients: a UK national cohort study. Clin J Am Soc Nephrol 2013;8(2):290–298. doi: 10.2215/CJN.06170612
59. Piccoli GB, Cabiddu G, Attini R et al. Outcomes of Pregnancies After Kidney Transplantation: Lessons Learned from CKD. A Comparison of Transplanted, Nontransplanted Chronic Kidney Disease Patients and Low-Risk Pregnancies: A Multicenter Nationwide Analysis. Transplantation 2017;101(10):2536–2544. doi: 10.1097/TP.0000000000001649
60. Webster P, Lightstone L, McKay DB, Josephson MA. Pregnancy in chronic kidney disease and kidney transplantation. Kidney Int 2017; 91(5):1047–1056. doi:10.1016/j.kint.2016.10.045
61. Pietrzak B, Mazanowska N, Kociszewska-Najman B et al. Successful Pregnancy Outcome after In Vitro Fertilization in a Kidney Graft Recipient: A Case Report and Literature Review. Ann Transplant 2015;20:338–341. doi: 10.12659/AOT.893735
62. Norrman E, Bergh C, Wennerholm U-B. Pregnancy outcome and long-term follow-up after in vitro fertilization in women with renal transplantation. Hum Reprod 2015;30(1):205–213. doi: 10.1093/humrep/deu293
63. Tedeschi SK, Bermas B, Costenbader KH. Sexual disparities in the incidence and course of SLE and RA. Clin Immunol 2013;149(2):211–218. doi: 10.1016/j.clim.2013.03.003
64. Marder W, Vinet É, Somers EC. Rheumatic autoimmune diseases in women and midlife health. Womens Midlife Health [Internet] 2015 [cited 2017 Oct 19];1. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC5444314/
65. Ortona E, Pierdominici M, Maselli A. et al. Sex-based differences in autoimmune diseases. Ann Ist Super Sanita 2016;52(2):205–212. doi: 10.4415/ANN_16_02_12
66. Petri M. Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol 2002;16(5):847–858. PMID: 12473278
67. Weckerle CE, Niewold TB. The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies. Clin Rev Allergy Immunol 2011;40(1):42–49. doi:10.1007/s12016-009-8192-4
68. Scofield RH, Bruner GR, Namjou B et al. Klinefelter’s syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 2008;58(8):2511–2517. doi: 10.1002/art.23701
69. Pierdominici M and Ortona E. Estrogen Impact on Autoimmunity Onset and Progression: the Paradigm of Systemic Lupus Erythematosus. Int Trends in Immun 2013;1(2):24–34
70. Maselli A, Conti F, Alessandri C et al. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus. Biol Sex Differ [Internet] 2016 [cited 2017 Oct 19];7. Available from: https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4709986/
71. Kim SJ, Schätzle S, Ahmed SS et al. Increased cathepsin S in Prdm1(-/-) dendritic cells alters the TFH cell repertoire and contributes to lupus. Nat Immunol 2017;18(9):1016–1024. doi: 10.1038/ni.3793
72. Langefeld CD, Ainsworth HC, Cunninghame Graham DS et al. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun 2017;8:16021. doi: 10.1038/ ncomms16021
73. Niewold TB, Hua J, Lehman TJA et al. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007;8(6):492–502. doi: 10.1038/sj.gene.6364408
74. Tower C, Mathen S, Crocker I, Bruce IN. Regulatory T cells in Systemic Lupus Erythematosus and Pregnancy. Am J Reprod Immunol 2013;69(6):588–595. doi: 10.1111/aji.12081
75. 75. Almaani S, Meara A, Rovin BH. Update on Lupus Nephritis. CJASN 2016;CJN.05780616. doi: 10.2215/CJN.05780616
76. Buyon JP, Kim MY, Guerra MM et al. Kidney Outcomes and Risk Factors for Nephritis (Flare/De Novo) in a Multiethnic Cohort of Pregnant Patients with Lupus. Clin J Am Soc Nephrol 2017;12(6):940–946. doi: 10.2215/CJN.11431116
77. Yelin E, Yazdany J, Trupin L. Relationship Between Process of Care and a Subsequent Increase in Damage in Systemic Lupus Erythematosus. Arthritis Care & Research 2017;69(6):927–932. doi: 10.1002/acr.22977
78. Kaplowitz ET, Ferguson S, Guerra M et al. Socioeconomic Status Contributes to Racial/Ethnic Disparities in Adverse Pregnancy Outcomes among Women with Systemic Lupus Erythematosus. Arthritis Care Res 2017; 69 (6):833–841. doi: 10.1002/acr.23021
79. Myasoedova E, Crowson CS, Kremers HM et al. Is the incidence of rheumatoid arthritis rising?: results from Olmsted County, Minnesota, 1955-2007. Arthritis Rheum 2010;62(6):1576–1582. doi: 10.1002/art.27425
80. Goemaere S, Ackerman C, Goethals K et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol 1990;17(12):1620–1622 PMID: 2084234
81. de Man YA, Dolhain RJEM, van de Geijn FE et al. Disease activity of rheumatoid arthritis during pregnancy: results from a nationwide prospective study. Arthritis Rheum 2008;59(9):1241–1248
82. Icardi A, Araghi P, Ciabattoni M et al. Kidney involvement in rheumatoid arthritis. Reumatismo 2003;55(2):76–85. PMID: 12874640
83. Anders H-J, Vielhauer V. Renal co-morbidity in patients with rheumatic diseases. Arthritis Research & Therapy 201;13:222. doi: 10.1186/ar3256
84. Chiu H-Y, Huang H-L, Li C-H et al. Increased Risk of Chronic Kidney Disease in Rheumatoid Arthritis Associated with Cardiovascular Complications – A National Population-Based Cohort Study. PLOS ONE 2015;10(9):e0136508. doi: 10.1371/journal.pone.0153431
85. Vinet É, Bernatsky S, Hudson M et al. Effect of menopause on the modified Rodnan skin score in systemic sclerosis. Arthritis Research & Therapy 2014;16:R130. doi: 10.1186/ar4587
86. Sammaritano LR. Menopause in patients with autoimmune diseases. Autoimmun Rev 2012;11(6–7):A430–436. doi: 10.1016/j.autrev.2011.11.006
87. Penn H, Denton CP. Diagnosis, management and prevention of scleroderma renal disease. Curr Opin Rheumatol 2008;20(6):692–696. doi: 10.1097/BOR.0b013e3283108df7
88. Anders HJ, Wiebecke B, Haedecke C et al. MPO-ANCAPositive crescentic glomerulonephritis: a distinct entity of scleroderma renal disease? Am J Kidney Dis 1999;33(4):e3. PMID: 10196034
89. Zakharova EV, Makarova TA, Stolyarevich ES. ANCAAssociated Vasculitis in Patient with CREST-Syndrome – Case Report [Internet]. [cited 2017 Oct 19]. Available from: https://www. eertechz.com/Clinical-Nephrology/ACN-2-115.php
90. Eckardt K-U, Coresh J, Devuyst O et al. Evolving importance of kidney disease: from subspecialty to global health burden. Lancet 2013;382(9887):158–169. doi: 10.1016/S01406736(13)60439-0
91. Saran R, Robinson B, Abbott KC et al. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis 2017;69(3 Suppl 1):A7–8. doi: 10.1053/j.ajkd.2016.12.004
92. Liyanage T, Ninomiya T, Jha V et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 2015;385(9981):1975–1982. doi: 10.1016/S0140-6736-(14)61601-9
93. Ojo A. Addressing the global burden of chronic kidney disease through clinical and translational research. Trans Am Clin Climatol Assoc 2014;125:229–243; discussion 243-246
94. WHO. Addressing gender within primary health care reforms. In: WHO editor. Gender, women and primary health care renewal: a discussion paper [Internet]. [cited 2017 Oct 19]. Available from: http://apps.who.int/iris/bitstream/10665/44430/1/9789241564038_eng.pdf
95. Eguavoen ANT, Odiagbe SO, Obetoh GI. The Status of Women, Sex Preference, Decision-Making and Fertility Control in Ekpoma Community of Nigeria. J Soc Sci 2007; 15(1):43–49
96. Halle MP, Takongue C, Kengne AP et al. Epidemiological profile of patients with end stage renal disease in a referral hospital in Cameroon. BMC Nephrol 2015;16:59. doi: 10.1186/s12882-015-0044-2
97. Ajayi S, Raji Y, Bello T et al. Unaffordability of renal replacement therapy in Nigeria. Hong Kong Journal of Nephrology 2016;18:15–29
98. Kausz AT, Obrador GT, Arora P et al. Late initiation of dialysis among women and ethnic minorities in the United States. J Am Soc Nephrol 2000;11(12):2351–2357. PMID: 11095658
99. Coresh J, Byrd-Holt D, Astor BC et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J Am Soc Nephrol 2005;16(1):180–188. doi: 10.1681/ASN.2004070539
100. Adams SV, Rivara M, Streja E et al. Sex Differences in Hospitalizations with Maintenance Hemodialysis. J Am Soc Nephrol 2017;28(9):2721–2728. doi: 10.1681/ASN.2016090986
101. Ethier J, Mendelssohn DC, Elder SJ et al. Vascular access use and outcomes: an international perspective from the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant 2008;23(10):3219–3226. doi: 10.1093/ndt/gfn261
102. Depner TA. Prescribing Hemodialysis: The Role of Gender. Adv Ren Replace Ther 2003 Jan;10(1):71-77. doi: 10.1053/jarr.2003.50007
103. Sehgal AR. Outcomes of renal replacement therapy among blacks and women. Am J Kidney Dis 2000;35(4):S148–152. PMID: 10766013
104. Jindal RM, Ryan JJ, Sajjad I et al. Kidney transplantation and gender disparity. Am J Nephrol 2005;25(5):474–483. doi: 10.1159/000087920
105. Couchoud C, Bayat S, Villar E et al. REIN registry. A new approach for measuring gender disparity in access to renal transplantation waiting lists. Transplantation 2012; 94(5):513–519
106. Liu G, Li X, Liu T et al. Gender disparity of living donor renal transplantation in East China. Clin Transplant 2013;27(1):98–103. doi: 10.1111/ctr.12003
107. Naghibi O, Naghibi M, Nazemian F. Gender disparity in kidney transplantation. Saudi J Kidney Dis Transpl 2008;19(4):545– 550. PMID: 18580010
108. Bal MM, Saikia B. Gender bias in renal transplantation: are women alone donating kidneys in India? Transplant Proc 2007; 39(10):2961–2963. DOI: 10.1016/j.transproceed.2007.08.089
109. Hogan J, Couchoud C, Bonthuis M et al. Gender Disparities in Access to Pediatric Renal Transplantation in Europe: Data from the ESPN/ERA-EDTA Registry. Am J Transplant 2016;16(7):2097–2105. doi: 10.1111/ajt.13723
110. Gillespie A, Hammer H, Kolenikov S et al. Sex Differences and Attitudes toward Living Donor Kidney Transplantation among Urban Black Patients on Hemodialysis. Clin J Am Soc Nephrol 2014;9(10):1764–1772. doi: 10.2215/CJN.12531213
111. Salter ML, McAdams-Demarco MA, Law A et al. Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatr Soc 2014;62(5):843–849. doi: 10.1111/jgs.12801
112. Piccoli GB, Attini R, Cabiddu G et al. Maternal-fetal outcomes in pregnant women with glomerulonephritides. Are all glomerulonephritides alike in pregnancy? J Autoimmun 2017; 79: 91–98. doi: 10.1016/j.jaut.2017.01.008
113. Seeger H, Salfeld P, Eisel R et al. Complicated pregnancies in inherited distal renal tubular acidosis: importance of acid-base balance. J Nephrol 2017;30(3):455–460. doi: 10.1007/s40620-016-0370-x
114. Yefet E, Tovbin D, Nachum Z. Pregnancy outcomes in patients with Alport syndrome. Arch Gynecol Obstet 2016; 293(4):739–747. doi: 10.1007/s00404-015-3893-9
Review
For citations:
Piccoli G.B., Alrukhaimi M., Liu Zh., Zakharova E., Levin A. WHAT WE DO AND DO NOT KNOW ABOUT WOMEN AND KIDNEY DISEASES; QUESTIONS UNANSWERED AND ANSWERS UNQUESTIONED: REFLECTION ON WORLD KIDNEY DAY AND INTERNATIONALWOMAN’S DAY. Nephrology (Saint-Petersburg). 2018;22(2):12-25. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-2-12-25