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Рост интереса нефрологов к проблеме поражения почек при преэклампсии (ПЭ) обусловлен её высокой распространенностью (2–14% от всех беременностей) и непредсказуемым исходом. Патогенез поражения почек при ПЭ мало изучен, однако, установлена роль дисбаланса про- и антиангиогенных факторов – VEGF и sFlt-1 – как одного из важнейших патогенетических механизмов, лежащих в основе развития ПЭ. В статье приводятся современные данные о патогенезе и почечных проявлениях ПЭ на разных сроках её развития в сопоставлении с маркерами плацентарного ангиогенеза. Обсуждается роль дисбаланса системы sFlt-1/VEGF в формировании протеинурии, артериальной гипертензии и ренальной дисфункции при ПЭ, а также «ранней» ПЭ как фактора риска развития хронической болезни почек (ХБП).
Меркушева Людмила Игоревна, кандидат медицинских наук, врач-нефролог
117197, Москва, ул. Академика Опарина, д. 4.
Козловская Наталья Львовна - профессор, доктор медицинских наук, кафедра внутренних, профессиональных болезней и пульмонологии медико-профилактического факультета
119991, Москва, ул. Трубецкая, д. 8, стр. 2.
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Меркушева Л.И., Козловская Н.Л. ПОРАЖЕНИЕ ПОЧЕК ПРИ ПРЕЭКЛАМПСИИ: ВЗГЛЯД НЕФРОЛОГА (ОБЗОР ЛИТЕРАТУРЫ). Нефрология. 2018;22(2):30-38. https://doi.org/10.24884/1561-6274-2018-22-2-30-38
Merkusheva L.I., Kozlovskaya N.L. RENAL INJURY IN PREECLAMPSIA: THE VIEW OF NEPHROLOGIST (LITERATURE REVIEW). Nephrology (Saint-Petersburg). 2018;22(2):30-38. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-2-30-38
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