RENAL INJURY IN PREECLAMPSIA: THE VIEW OF NEPHROLOGIST (LITERATURE REVIEW)
https://doi.org/10.24884/1561-6274-2018-22-2-30-38
Abstract
The growing interest of nephrologists in the problem of kidney injury in preeclampsia is due to its high prevalence (2–14% of all pregnancies) and unpredictable outcome. The pathogenesis of kidney injury in PE is poorly known, however, the role of imbalance of pro- and anti-angiogenic factors – VEGF and sFlt-1 – has been established as one of the most important pathogenetic mechanisms underlying the development of PE. The article presents modern data on the pathogenesis and renal manifestations of PE at different times of its development in comparison with markers of placental angiogenesis. The role of the imbalance of the sFlt-1 / VEGF system in the formation of proteinuria, arterial hypertension and renal dysfunction in PE is discussed, as well as the role of “early” PE as a risk factor for the development of chronic kidney disease.
About the Authors
L. I. Merkusheva
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academical V.I. Kulakov of Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Liudmila I. Merkusheva, MD, PhD
117197, Moscow, ac. Oparina str. 4
N. L. Kozlovskaya
First Moscow State Medical Sechenov University
Russian Federation
Russian Federation
Natalia L. Kozlovskaya, Prof. MD, PhD, DSci, Department of Internal and Occupational Medicine, Faculty of Preventive Medicine
119991, Moscow, Trubetskaya, 8-2 str.
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For citations:
Merkusheva L.I., Kozlovskaya N.L. RENAL INJURY IN PREECLAMPSIA: THE VIEW OF NEPHROLOGIST (LITERATURE REVIEW). Nephrology (Saint-Petersburg). 2018;22(2):30-38. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-2-30-38
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