CALCIDIOL IN CHILDREN WITH CHRONIC KIDNEY DISEASE STAGES 2–5

Vitamin D deficiency is characteristic for patients with chronic kidney disease (CKD). THE AIM: to study the prevalence of deficits of calcidiol in children with CKD, and to establish correlations with parathyroid hormone and other markers of bone mineral metabolism in children. PATIENTS AND METHODS. In the period from September 2015 to December 2016 we examined of calcidiol in 53 boys and 32 girls with CKD stages 2-5. The average age of the patients was 11.3+4,7 years. RESULTS. 92.5% of cases in children with CKD revealed a low level of calcidiol. Of them, 30.6% of children were in deficit of vitamin D. The incidence of vitamin D deficiency correlated with a decrease in glomerular filtration rate (r = 0.31; p<0.05). We identified an inverse relationship between calcidiol levels and serum parathyroid hormone, and calcium-phosphorous product (r= -0,29, and r= -0,31; p><0.05, respectively). Predictors of vitamin D deficiency may be hypoalbuminemia and hyperphosphaturia. CONCLUSION. Determination of vitamin D in children with CKD is extremely important for timely correction and prevention of the development of secondary hyperparathyroidism. Just started the correction of bone and mineral metabolism will improve the quality of life for children with CKD and prevent the development of such complications of hyperparathyroidism as bone deformation and vessels calcification. Keywords: CKD, vitamin D, parathyroid hormone, calcium x phosphorous product>< 0.05). We identified an inverse relationship between calcidiol levels and serum parathyroid hormone, and calcium-phosphorous product (r= -0,29, and r= -0,31; p< 0.05, respectively). Predictors of vitamin D deficiency may be hypoalbuminemia and hyperphosphaturia. CONCLUSION. Determination of vitamin D in children with CKD is extremely important for timely correction and prevention of the development of secondary hyperparathyroidism. Just started the correction of bone and mineral metabolism will improve the quality of life for children with CKD and prevent the development of such complications of hyperparathyroidism as bone deformation and vessels calcification.

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