THE FUNCTIONAL STATE OF ENDOTHELIUM IN PATIENTS WITH CAROTID ARTERY CALCIFICATION ON CHRONIC HAEMODIALYSIS
https://doi.org/10.24884/1561-6274-2011-15-1-37-42
Abstract
THE AIM of the investigation was to determine the role of dysfunction of endothelium in mechanisms of carotid artery (CA) calcification in patients with endstage renal disease undergoing chronic haemodialysis (HD). PATIENTS AND METHODS. 94 HD patients (men/women, 52/42; age 46,4±11,2 years) were included in the study (HD duration, 28,9±32,4 months) with implementation of ultrasound scanning of CA. Research of morphofunctional state of extracranial vessels was carried out using standard approaches. Echogenicity of carotid plaques (14) was estimated according to GrayWeale classification. Depending on ultrasound morphology of carotid plaques, three groups of patients were formed: 1st group – without plaques – (n=31), 2nd – hypoechogenic plaques – (n=21), 3rd – hyperechogenic plaques – (n=42). Vasomotor function of the brachial artery (BA) was distinguished in the test with reactive hyperemia (endotheliumdependent vasodilation (EDVD), and sensitivity of BA to shear stress (K) was also estimated accordingly. Plasma content of nitrite (NO2 –) and nitrateanions (NO3–), and amount of circulating endothelial cells (СECs) were measured. RESULTS. In the groups of patients with the presence of echogenic carotid plaques content of NO2 – was below both in relation to a group without plaques (р=0,003) and with hypoechogenic plaques (р=0,008), and content of NO3
– in the mentioned groups was not significantly different. HDpatients with calcified plaques in CA compared to patients with soft plaques showed lower indexes of EDVD (р=0,001), shear stress (К, р=0,017), higher amount of CECs (p=0,007), and vasoconstriction (EDVD<0) and undilatation (EDVD=0) reactions (p=0,032) appeared more often. CONCLUSION. Calcification of CA in patients on chronic HD was combined with damage of endothelium, disturbance of vasoreativity and deficit of nitric oxide (NO). Defect of NO system can be the factor in the formation of carotid plaques calcification.
– in the mentioned groups was not significantly different. HDpatients with calcified plaques in CA compared to patients with soft plaques showed lower indexes of EDVD (р=0,001), shear stress (К, р=0,017), higher amount of CECs (p=0,007), and vasoconstriction (EDVD<0) and undilatation (EDVD=0) reactions (p=0,032) appeared more often. CONCLUSION. Calcification of CA in patients on chronic HD was combined with damage of endothelium, disturbance of vasoreativity and deficit of nitric oxide (NO). Defect of NO system can be the factor in the formation of carotid plaques calcification.
About the Authors
A. I. GOZHENKO
Украинский научно-исследовательский институт медицины транспорта
Russian Federation
Russian Federation
A. B. SUSLA
Тернопольский государственный медицинский университета им. И.Я. Горбачевского, Тернопольскаяуниверситетская больница
Russian Federation
Russian Federation
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Review
For citations:
GOZHENKO A.I., SUSLA A.B. THE FUNCTIONAL STATE OF ENDOTHELIUM IN PATIENTS WITH CAROTID ARTERY CALCIFICATION ON CHRONIC HAEMODIALYSIS. Nephrology (Saint-Petersburg). 2011;15(1):37-42. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-1-37-42
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