Хемерин. Роль в регуляции воспаления и возможности изучения в нефрологии
Аннотация
Хемерин, который представляет собой белок, состоящий из 131-137 аминокислот и экспрессирующийся преимущественно в жировой ткани. Эффекты хемерина реализуются путем воздействия на хемокиноподобный рецептор (chemokine-like receptor 1 - CMKLR1). CMKLR1 экспрессируются на дендритных клетках как миелоидного, так и плазмоидного ряда, тем самым участвуя в реакциях как врождённого, так и приобретенного иммунитета. Помимо метаболических эффектов хемерина, описаны ряд реакций, имеющих прямое или косвенное отношение к воспалительному ответу, в которых хемерин и его рецепторы продемонстрировали свое участие. Хемерин стимулирует адгезию макрофагов к фибронектину, молекулам адгезии - ICAM-1 (intercellular adhesion molecule-1) и VCAM-1 (vascular cell adhesion molecule-1) [29]. Адгезивные эффекты хемерина реализуются через воздействие на CMKLR1, расположенные на мембране макрофагов. Анализ роли хемерина в воспалительном процессе позволяет предполагать его значение в развивающемся воспалении в почечной ткани при гломерулонефрите и тубулоинтерстициальном нефрите. Исследований по данной проблеме в настоящее время недостаточно. Поскольку протеазы непосредственно участвуют в активации прохемерина, связь их высоких концентраций с почечным повреждением, в том числе макрофагальной инфильтрацией и увеличением объема межуточного пространства почечной ткани, может опосредоваться повышенным уровнем активированного хемерина.
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Рецензия
Для цитирования:
Батюшин М.М. Хемерин. Роль в регуляции воспаления и возможности изучения в нефрологии. Нефрология. 2014;18(5):8-15.
For citation:
Batyushin M.M. Chemerin. Role in the regulation of inflammation and the possibility of studying in nephrology. Nephrology (Saint-Petersburg). 2014;18(5):8-15. (In Russ.)
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