Положительный контур мочевой кислоты, гомоцистеина, NOX и XOR: нефрологические аспекты

Согласно современным молекулярно-биологическим представлениям, мочевая кислота и гомоцистеин являются активаторами и участниками прооксидантного контура положительных обратных связей, включающего также ксантиноксидоредуктазу и НАДФ∙H-оксидазные комплексы в качестве непосредственных прооксидантных агентов. В силу физиологических и биохимических особенностей почки могут быть одним из наиболее подверженных влиянию этого контура органов. В настоящем обзоре в нефрологическом аспекте представлены биохимические, физиологические и интерактомные эффекты как собственно указанного контура, так и его отдельных компонентов.

мочевая кислота, гомоцистеин, НАДФ∙H-оксидаза, ксантиноксидоредуктаза, контур положительных обратных связей, окислительный стресс, гибель клеток, почка, мочевая кислота, гомоцистеин, НАДФ∙H-оксидаза, ксантиноксидоредуктаза, контур положительных обратных связей, окислительный стресс, гибель клеток, почка

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