GENDER CHARACTERISTICS OF LIPIDOCORRECTING AND NEPHROPROTECTING EFFECTS OF DIFFERENT VARIANTS OF HYPOLIPIDEMIC THERAPY APPLICATION TO PATIENTS WITH METABOLIC SYNDROME

OBJECTIVE: to evaluate gender characteristics of lipid correcting and nephroprotecting effects of different variants of hypolipidemic therapy application to patients with metabolic syndrome (MetS). PATIENTS AND METHODS. The research involves 172 patients with MetS (81 males and 91 females) who were administered original simvastatin (MSD) 20 mg/per day, achieving the target level low density lipoprotein cholesterol (LDL-C) in 29 patients. The remaining patients were randomized into 2 groups: in the first the dose of simvastatin was increased to 40 mg/per day, the second group patients were administered the fixed combination: simvastatin 20 mg + ezetimibe 10mg (MSD). Initially, after 1, 2 and 6 months data of lipid profile were evaluated, C-reactive protein (CRP), microalbuminuria, blood creatinin and glomerular filtration rate (GFR) (MDRD). Results. Simvastatin 40mg/per day ensured the attaining of a target level of LDL-C with 81.2 % of males and 55.9 % of females (t<0.05), and the combination «simvastatin + ezetimibe» – 86,8 % of females and 64.1% of males (t<0.05). The application of simvastatin, as well as the fixed combination «simvastatin 20mg + ezetimibe 10 mg» ensured the significant reduction of microalbuminuria and the increasing of GFR regardless of sex, nevertheless the application of statin made more significant effect on the renal function with males whereas the therapy with combination «simvastatin 20mg + ezetimibe 10mg» of females in the degree of change of microalbuminuria and GFR gave better results than the same treatment of males. CONCLUSION. The combined therapy with MetS provides more considerable lipid correcting and nephroprotecting effects on females compared with males.

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