Factorial analysis for forecasting the development of microalbuminuria in patients with coronary heart disease showing the contribution of local coronary factors
Abstract
THE AIM: to estimate influence of risk factors and parameters of local coronary factors on probability of development of microalbuminuria (MAU) at patients with ischemic heart disease (IHD) and indications to myocardial revascularization. PATIENTS AND METHODS. Research included 90 patients with IHD and indications to recovery of an intracoronary blood circulation. At entry into the study we evaluated the severity of the clinical status of each respondent and analysis of the prevalence of risk factors. RESULTS. As a result of the conducted research a number of risk factors was established, which significantly increase the probability of development of MAU., such as presence of postinfarction cardiosclerosis, atrial fibrillation, acceleration of cardiac rhythm, some parameters of local coronary factors, showing the severity of atherosclerotic damage of the coronary vessels. We establish additional risk factors, the existence of which exacerbates the impact of the major risk factors for the development of MAU. CONCLUSION. The presence of MAU reflects the overall severity of the pathological process in the cardiovascular and renal systems, as an integral marker of poor prognosis. Identified predictors of cardiovascular events associated with the formation of albuminuria.
About the Authors
E. S. Levitskaya
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
M. M. Batyushin
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
G. V. Shavkuta
Ростовский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Мензоров М.В., Шутов А.М., Серов В.А. и др. Острое повреждение почек у больных инфарктом миокарда с подъемом сегмента ST. Нефрология 2012; 16 (1): 40-44.
2. Ronco C., Haapio M., House A.A. et al. Cardiorenal Syndrome. J Am Coll Cardiol 2008; (52): 1527-1539.
3. Гарсиа-Донаире Ж.А., Руилопе Л.М. Кардио-васкулярноренальные связи в кардиоренальном континууме. 2013; 17(1): 11-19.
4. Смирнов А.В., Каюков И.Г., Добронравов В.А. Концепция факторов риска в нефрологии: Вопросы профилактики и лечения хронической болезни почек. Нефрология 2008; 12(1): 7-13.
5. Национальные рекомендации. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Клиническая нефрология - 2012; (4): 4-26.
6. Левицкая Е.С., Батюшин М.М., Терентьев В.П. и др. Оценка влияние почечных факторов риска и параметров коронарной атеросклеротической бляшки на вероятность развития рецидива стенокардии у больных, подвергшихся реваскуляризации миокарда. Клиническая нефрология 2012; (3): 30-33.
7. Odden M.C., Coxson P.G., Moran A. et al. The Impact of the Aging Population on Coronary Heart Disease in the United States. American Journal of Medicine 2011; 124(9): 827-833.
8. Панина И.Ю., Румянцев А.Ш., Меншутина М.А. и др. Особенности функции эндотелия при хронической болезни почек. Обзор литературы и собственные данные. Нефрология 2007; 11(4): 28-46.
9. Мухин Н.А., Арутюнов Г.П., Фомин В.В. Альбуминурия - маркер поражения почек и риска сердечно-сосудистых осложнений. Клиническая нефрология 2009; (1): 5-10.
10. DeFilippis A.P., Kramer H.J., Katz R. et al. Association Between Coronary Artery Calcification Progression and Microalbuminuria. J Am Coll Cardiol Img 2010; (3): 595-604.
11. Батюшин М.М., Левицкая Е.С., Терентьев В.П. и др. Почечные и коронарные предикторы прогноза у больных ишемической болезнью сердца, перенесших реваскуляризацию миокарда. Российский кардиологический журн. 2012; 6(98): 45-50.
12. Pontremoli R., Leoncini G., Ravera M. et al. Microalbuminuria, Cardiovascular, and Renal Risk in Primary Hypertension JASN 2002; 13 [suppl 3]: 169-172.
13. Böhm M., Thoenes M., Neuberger H.R. et al. Atrial fibrillation and heart rate independently correlate to microalbuminuria in hypertensive patients. Eur Heart J 2009; 11(30): 1364-1371.
14. Bohm M., Reil J.C., Danchin N. et. al. Association of heart rate with microalbuminuria in cardiovascular risk patients: data from i-SEARCH. J Hypertens 2008; (26): 18-25.
15. Ceconi C., Guardigli G., Rizzo P., et al. The heart rate story. Eur Heart J 2011; 13 [suppl C]: 4-13.
16. Fox K.M. Current status: heart rate as a treatable risk factor. Eur Heart J 2011; [13 suppl C]: 30-36.
17. Hata J., Woodward M. et al. Resting Heart Rate and the Risk of Microvascular Complications in Patients With Type 2 Diabetes Mellitus. J Am Heart Assoc 2012; (1): е002832.
18. Koroshi A. Microalbuminuria, is it so important? Hippokratia 2007; 11(3): 105-107.
19. Lopes N.H., Paulitsch F.S., Pereira A. et al. Mild chronic kidney dysfunction and treatment strategies for stable coronary artery disease. Journal of Thoracic and Cardiovascular Surgery 2009; 6(137): 1443-1449.
20. Barbosa R.R., Cestari P.F., Capeletti J.T. et al. Impact of Renal Failure on In-hospital Outcomes after Coronary Artery Bypass Surgery. Arquivos brasileiros de cardiologia 2011; 97(3): 249-253.
Review
For citations:
Levitskaya E.S., Batyushin M.M., Shavkuta G.V. Factorial analysis for forecasting the development of microalbuminuria in patients with coronary heart disease showing the contribution of local coronary factors. Nephrology (Saint-Petersburg). 2014;18(5):35-43. (In Russ.)
Views:
422
Email this article 