UNDERCARBOXYLATED OSTEOCALCIN IN POSTMENOPAUSAL PATIENTS ON HEMODIALYSIS
https://doi.org/10.24884/1561-6274-2011-15-3-35-39
Abstract
Osteocalcin is a vitamin K-dependent protein secreted by osteoblasts. In vitamin K deficiency the fraction of the inactive, undercarboxylated osteocalcin (ucOC) is increased. Chronic kidney disease is associated with bone loss and there is evidence for a sub-optimal status of vitamin K in renal patients. THE AIM of the present study was to assess the vitamin K status in postmenopausal hemodialysis patients based on their ucOC level with the background idea to substantiate the need of vitamin K supplementation. PATIENTS AND METHODS. 78 postmenopause women were divided into 3 groups: 1) women on hemodialysis; 2) a control group with normal bone mineral density; 3) osteoporosis group. Serum ucOC was measured immunochemically. Osteoporosis was verified by DEXA scan of the radius. RESULTS. Serum ucOC in hemodialysis women was significantly increased in comparison with control and osteoporosis group, which did not differ significantly between each other. In hemodialysis patients, a strong positive correlation was found between ucOC and parathormone and between ucOC and hemodialysis duration. CONCLUSION. The increase of ucOC in hemodialysis postmenopausal patients may indicate a severe vitamin K deficit, but other factors may also contribute. Therefore, additional investigation is needed to justify supplementation with vitamin K in these patients.
About the Authors
M. D. ZHELYAZKOVA-SAVOVABulgaria
B. Tz. GALUNSKA
Bulgaria
D. I. GEROVA
Центр клинической лабораторной диагностики госпиталя Св. Марина
Bulgaria
Bulgaria
T. G. CHERVENKOV
госпиталь Св. Марина
Russian Federation
Russian Federation
M. V. SIDEROVA
Клиника эндокринологии госпиталя Св. Марина
Russian Federation
Russian Federation
R. J. ZORCHEVA
Клиника нефрологии и диализа госпиталя Св. Марина Медицинского
университета
Russian Federation
Russian Federation
D. N. PASKALEV
Клиника нефрологии и диализа госпиталя Св. Марина Медицинского
университета
Russian Federation
Russian Federation
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Review
For citations:
ZHELYAZKOVA-SAVOVA M.D., GALUNSKA B.T., GEROVA D.I., CHERVENKOV T.G., SIDEROVA M.V., ZORCHEVA R.J., PASKALEV D.N. UNDERCARBOXYLATED OSTEOCALCIN IN POSTMENOPAUSAL PATIENTS ON HEMODIALYSIS. Nephrology (Saint-Petersburg). 2011;15(3):35-39. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-3-35-39
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