PROSTAGUT-FORTE IN BENIGN PROSTATIC HYPERPLASIA TREATMENT
https://doi.org/10.24884/1561-6274-2011-15-3-45-50
Abstract
THE AIM of the research was investigation of Prostagut-forte phytogenic drug efficiency in treatment of BPH patients. PATIENTS AND METHODS. Treatment was provided for 86 patients with BPH, clinically manifested by symptoms of lower urinary tract. All patients were assigned 1 capsule of prostagut-forte (280 mg) 2 times a day during 6 months as monotherapy. RESULTS. Obtained data shown efficiency of prostagut-forte usage at patients with BPH. 68 patients (79,1%) at the end of treatments 1 month pointed out symptomatology improving. In quoted period score decreasing on I-PSS scale compounds accordingly - 31,9%,-38,6% and -41%. The subjective improvement accompanied by increasing of measurements characterising urine outflow from urinary bladder. Maximal urine flow speed average increased on +30,8% and residual urine volume decreased on -48,4% to the end of treatment. Evidential prostate size and PSA level alteration is not noticed during treatment. Most quick effect was noticed at first therapy month. CONCLUSION. Provided research approved that prostagut-forte prescription inspires clinical BPH appearances intensity decreasing. Prostagut-forte therapeutic action based on occurrence antiandrogenic, anti-inflammatory and immunomodulatory effect in preparation. Application during treatment of patients with BPH may consider pathogenetic reasonably, as long as it influences on basic disease pathogenesis component.
About the Authors
S. H. AL-SHUKRI
СанктПетербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
I. V. KUZMIN
СанктПетербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
References
1. Гориловский ЛМ. Эпидемиология, факторы риска развития и биологическое течение доброкачественной гиперплазии предстательной железы. В: Лопаткин НА, ред. Доброкачественная гиперплазия предстательной железы. М., 1999; 12-20
2. Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Uro 1984;132:474-479
3. Stovsky MD, Rhee K, Hartke D. Medical therapy versus surgery and minimally invasive surgical therapies for lower urinary tract symptoms and benign prostatic hyperplasia: what makes better economic sense? Curr Urol Rep 2007;8(4):289-297
4. McConnell JD. Prostatic growth: new insights into hormonal regulation. Br J Urol 1995;76[suppl 1]: 5-10
5. Lepor H. Pathophysiology, Epidemiology, and Natural History of Benign Prostatic Hyperplasia. Rev Urol 2004; 6 [suppl 9]: S3-S10
6. Walsh PC, Hutchins GM, Ewing LL. Tissue content of dihydrotestosterone in human prostatic hyperplasia is not supernormal. J Clin Invest 1983;72:1772-1777
7. Nickel JC. Inflammation and Benign Prostatic Hyperplasia Urol Clin North Am 2008; 35(1): 109-115
8. Robert G, Salagierski M, Schalken JA, de La Taille A. Inflammation and benign prostatic hyperplasia: cause or consequence? Prog Urol 2010;20(6):402-407
9. Roberts RO, Lieber MM, Rhodes T et al. Prevalence of a physician-assigned diagnosis of prostatitis: the Olmsted County Study of Urinary Symptoms and Health Status Among Men. Urol 1998;51:578-584
10. Collins MM, Meigs JB, Barry MJ et al. Prevalence and correlates of prostatitis in the health professionals follow-up study cohort. J Urol 2002;167(3):1363-1366
11. Nickel JC, Roehrborn CG, O'Leary MP et al. The relationship between prostate inflammation and lower urinary tract symptoms: examination of baseline data from the REDUCE trial. J Urol 2007;177[suppl 14]: 34-35
12. Buck AC. Is there a scientific basis for the therapeutic effects of serenoa repens in benign prostatic hyperplasia? Mechanisms of action. J Urol 2004;172:1792-1799
13. St Sauver JL, Jacobson DJ, McGree ME et al. Association between prostatitis and development of benign prostatic hyperplasia. J Urol 2007;177[suppl 4]: 497
14. Kramer G, Marberger M. Could Inflammation be a key component in the progession of benign prostatic hyperplasia? Curr Opin in Urol 2006;16:25-29
15. Kohnen PW, Drach GW. Patterns of inflammation in prostatic hyperplasia: a histologic and bacteriologic study. J Urol 1979;121:755-760
16. Kramer G, Steiner GE, Handisurya A et al. Increased expression of lymphocyte-derived cytokines in benign hyperplastic Prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation. Prostate 2002;52: 43-48
17. Lee KL, Peehl D. Molecular and cellular pathogenesis of benign prostatic hyperplasia. J Urol 2004;172:1784-1791
18. Kramer G, Mitteregger H, Marberger M. Is Benign Prostatic Hyperplasia (BPH) an Immune Inflammatory Disease? Europ Urol 2007;51:1202-1216
19. Lopatkin N, Sivkov A, Walther C et al. Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms-a placebo-controlled, double-blind, multicenter trial. World J Urol 2005; 23(2):139-146
20. Лопаткин Н.А., Сивков А.В., Медведев А.А. и др. Комплексное лечение больных аденомой предстательной железы с использованием Простагут форте. Урология 2006; (2):12, 14-19
21. Engelmann U, Walther C, Bondarenko B et al. Efficacy and safety of a combination of sabal and urtica extract in lower urinary tract symptoms. A randomized, double-blind study versus tamsulosin. Arzneimittelforschung 2006;56(3):222-229
22. Lopatkin N, Sivkov A, Schlafke S et al. Efficacy and safety of a combination of Sabal and Urtica extract in lower urinary tract symptoms -long-term follow-up of a placebo-controlled, double-blind, multicenter trial. Int Urol Nephrol 2007; 39(4):1137-1146
23. Неймарк А.И., Давыдов А.В. Комплексное лечение больных аденомой предстательной железы с использованием Простагут форте. Русский медицинский журнал 2008; 29:2010-2011
Review
For citations:
AL-SHUKRI S.H., KUZMIN I.V. PROSTAGUT-FORTE IN BENIGN PROSTATIC HYPERPLASIA TREATMENT. Nephrology (Saint-Petersburg). 2011;15(3):45-50. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-3-45-50
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