THYROID STATUS IN CHILDREN WITH STEROIDSENSITIVE NEPHROTIC SYNDROME
https://doi.org/10.24884/1561-6274-2011-15-3-51-55
Abstract
THE AIM. The purpose of the research was to study thyroid status in children with steroid-sensitive nephrotic syndrome (SSNS) in relapse and remission. PATIENTS AND METHODS. The study included 44 children with SSNS in active period (n=10) and in remission (n=38). Thyroid-stimulating hormone (TSH), total thyroxine (T4), free thyroxine (FT4), triiodothyronine (T3), anti-microsomal antibody, anti-thyroglobulin antibody were assayed by enzyme-linked immunosorbent assay. RESULTS. Six from 10 patients in active period of SSNS had elevated TSH levels (7,95±3,23 uIU/ml). Four patients among them had normal T4 and FT4 levels: latent hypothyroidism was diagnosed. Two of six patients with severe hypoalbuminaemia had the reduction of T4 and FT4: hypothyroidism was diagnosed. In remission of SSNS were examined 38 patients. All patients had TSH, T4 and FT4 within normal range, including 4 children with hypothyroidism in relapse of SSNS. Autoimmune thyroiditis was diagnosed in three children. The mean serum T4 concentration was lower (p<0,05) and TSH higher (p<0,05) in relapse than in remission of SSNS. Т4 showed a moderate positive correlation with the serum total protein and albumin (p<0,01). Serum albumin showed a significant negative correlation with the TSH (p<0,01). T4 showed a moderate negative correlation with the cholesterol and low-density lipoprotein (p<0,01). CONCLUSION. The exchanges of thyroid status as a hypothyroidism are detected in active period of SSNS in children. The hypothyroidism is associated with proteinuria and hypoalbuminaemia and is reversible. Autoimmune thyroiditis in children with SSNS was diagnosed in 6,8% of cases.
About the Authors
M. M. SMIRNOVA
Научно-исследовательский центр Санкт-Петербургской государственной педиатрической медицинской академии
Russian Federation
Russian Federation
N. D. SAVENKOVA
Научно-исследовательский центр Санкт-Петербургской государственной педиатрической медицинской академии
Russian Federation
Russian Federation
L. V. TYRTOVA
Научно-исследовательский центр Санкт-Петербургской государственной педиатрической медицинской академии
Russian Federation
Russian Federation
O. P. GURINA
Научно-исследовательский центр Санкт-Петербургской государственной педиатрической медицинской академии
Russian Federation
Russian Federation
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Review
For citations:
SMIRNOVA M.M., SAVENKOVA N.D., TYRTOVA L.V., GURINA O.P. THYROID STATUS IN CHILDREN WITH STEROIDSENSITIVE NEPHROTIC SYNDROME. Nephrology (Saint-Petersburg). 2011;15(3):51-55. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-3-51-55
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