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МИКРОБИОТА КИШЕЧНИКА И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК. СООБЩЕНИЕ ПЕРВОЕ

https://doi.org/10.24884/1561-6274-2018-22-4-57-73

Полный текст:

Аннотация

Интерес к изучению роли желудочно-кишечного тракта в поддержании гомеостаза при хронической болезни почек является традиционным. Он послужил, в частности, отправной  точкой для создания энтеросорбентов. Однако, если ранее основное внимание было  обращено на механическое удаление ряда потенциально опасных биологически активных  веществ, то в последнее время предметом интереса стала кишечная микробиота. Первая  часть обзора литературы на эту тему посвящена вопросам терминологии, нормальной  физиологии микробиоты толстой кишки. Дана подробная характеристика дисбиоза. Отражены особенности  основных групп микроорганизмов. Представлены гипотетические и подтвержденные  взаимосвязи оси кишечник–почки. Обсуждены патогенетические механизмы влияния дисбиоза  толстой кишки на процессы местного и системного воспаления. Дебатируются влияния  дисбиоза на состояние паренхимы почек и его участие в прогрессировании ХБП.

Об авторах

Б. Г. Лукичев
Первый Санкт-Петербургский государственный медицинский университет
Россия

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

Проф. Лукичев Борис Георгиевич, д-р мед. наук, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65



А. Ш. Румянцев
Первый Санкт-Петербургский государственный медицинский университет Санкт-Петербургский государственный университет
Россия

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

199106, Санкт-Петербург, 21-я линия В.О., д. 8а

Проф. Румянцев Александр Шаликович, д-р мед наук, кафедра факультетской терапии Тел.: +7 (812) 326-03-26



В. Акименко
Первый Санкт-Петербургский государственный медицинский университет
Россия

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

Акименко Вера, кафедра пропедевтики внутренних болезней, студент. Тел.: (812)-234-01-65



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Для цитирования:


Лукичев Б.Г., Румянцев А.Ш., Акименко В. МИКРОБИОТА КИШЕЧНИКА И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК. СООБЩЕНИЕ ПЕРВОЕ. Нефрология. 2018;22(4):57-73. https://doi.org/10.24884/1561-6274-2018-22-4-57-73

For citation:


Lukichev B.G., Rumyantsev A.S., Akimenko V. COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASE. MESSAGE ONE. Nephrology (Saint-Petersburg). 2018;22(4):57-73. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-4-57-73

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