THE VALUE OF STUDIES OF TAMM-HORSFALL PROTEIN IN PATIENTS WITH BILATERAL RECURRENT NEPHROLITHIASIS
https://doi.org/10.24884/1561-6274-2013-17-2-101-103
Abstract
THE AIM of the study was to determination of concentration and role of Tamm-Horsfall protein (THP) in the pathogenesis of recurrent nephrolithiasis. PATIENTS AND METHODS. The study included 62 patients with bilateral recurrent nephrolithiasis, 34 patients with unilateral nephrolithiasis and 20 patients in the control group. THP was isolated from the daily urine of patients with light dynamic scattering method, which produces a histogram of particle size distribution in the range from a few nanometers to tens of microns, while maintaining the properties of native substrates. RESULTS. The average value of THP particles length in control group was 138,4 ± 1,7 nm. In the group with unilateral nephrolithiasis mean THP particles length was 186.2 ± 2,1 nm. Mean wavelength of THP in patients with bilateral nephrolithiasis was 1962.4 ± 12.3nm. CONCLUSION. THP concentration in patients with bilateral recurrent nephrolithiasis is much higher than that of patients in study groups, which may be the basis for a new approach to the early diagnosis of urolithiasis, and development of new pharmacological methods of stone formation prevention.
About the Authors
S. H. Al-Shukri
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
M. I. Gorbachev
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
E. T. Goloschapov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Al-Shukri S.H., Gorbachev M.I., Goloschapov E.T. THE VALUE OF STUDIES OF TAMM-HORSFALL PROTEIN IN PATIENTS WITH BILATERAL RECURRENT NEPHROLITHIASIS. Nephrology (Saint-Petersburg). 2013;17(2):101-103. (In Russ.) https://doi.org/10.24884/1561-6274-2013-17-2-101-103
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