ACUTE KIDNEY INJURY AT PATIENTS WITH ST-ELEVATED MYOCARDIAL INFARCTION
https://doi.org/10.24884/1561-6274-2012-16-1-40-44
Abstract
AIM. To estimate frequency and intensity of acute kidney injury (AKI) by RIFLE and AKIN criteria at patients with ST-elevated myocardial infarction (STEMI), to specify connection between AKI and mortality and effectivness of thrombolytic therapy (TLT). PATIENTS AND METНODS. 165 patients (134 men and 31 women, average age 56,6±10,43 years) with STEMI, who were performed TLT. AKI was diagnosed and classified by RIFLE and AKIN criteria by creatinine (RIFLECr, AKINCr) and diuresis (RIFLEOU, AKINOU). RESULTS. TLT was effective at 115 patients (70%). According to RIFLECr AKI was diagnosed at 87 patients (53%), by AKINCr criteria – at 101 patients (61%). According to RIFLEOU and AKINOU criteria AKI was noticed at 56 patients (34%). 9 patients (5%) died. Logistic regression analysis showed that AKI about RIFLEOU and AKINOU was time and age independent from the beginning of characteristic clinical picture till hospitalization associated with intrahospital mortality (hazard ratio 17,1; 95% CI 2,01 – 146.46; p=0,006). CONCLUSION. More then half of patients with STEMI have AKI by RIFLECr and AKINCr criteria. AKI frequency by RIFLEOU and AKINOU is twice as little in comparison with evaluation by AKINCr and 40% fewer in comparison with evaluation by RIFLECr, AKI presence is associated with effect absence from thrombolytic therapy and increased intrahospital mortality.
About the Authors
M. V. MenzorovRussian Federation
A. M. Shutov
Russian Federation
V. A. Serov
Russian Federation
E. V. Michajlova
Russian Federation
T. V. Klimova
Russian Federation
E. A. Astapenko
Russian Federation
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Review
For citations:
Menzorov M.V., Shutov A.M., Serov V.A., Michajlova E.V., Klimova T.V., Astapenko E.A. ACUTE KIDNEY INJURY AT PATIENTS WITH ST-ELEVATED MYOCARDIAL INFARCTION. Nephrology (Saint-Petersburg). 2012;16(1):40-44. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-1-40-44