NOCTURNAL ENURESIS IN CHILDREN
https://doi.org/10.24884/1561-6274-2012-16-3/2-16-24
Abstract
Modern data about prevalence, etiology and pathogenesis of nocturnal enuresis are presented. The nocturnal enuresis meets at children till 5 years in 15 % of cases. It is a heterogeneous disorder with a whole variety of etiologic factors (genetic, endocrinological, neurobiological), particularly a dysfunction of the lower urinary tract. This is polietiologic disease in which development various factors (genetic, endocrine, neurogenetic), being accompanied dysfunction of the bottom urinary ways can take part. Despite the prevalence of enuresis many questions regarding its pathophysiological mechanisms remain disputable. There are three pathogenetic mechanisms that have sufficient scientific support: nocturnal polyuria, nocturnal detrusor overactivity and high arousal thresholds. Nocturnal polyuria is often explained by a nocturnal lack of the antidiuretic pituitary hormone vasopressin. At primary nocturnal enuresis the urine incontience is noted at night from the moment of the birth. At secondary nocturnal enuresis arises in 6 months after the birth. Primary night enuresis associates with a night polyuriya, increased renal sodium excretion, higher secretion of prostaglandins. Desmopressin markedly reduced nocturnal urine output in patients with enuresis, minimizing sodium, urea and overall solute excretion.
About the Author
A. A. Kuznetsova
Санкт-Петербургская государственная педиатрическая медицинская академия, Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН
Russian Federation
Russian Federation
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For citations:
Kuznetsova A.A. NOCTURNAL ENURESIS IN CHILDREN. Nephrology (Saint-Petersburg). 2012;16(3/2):16-24. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-3/2-16-24
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