PHARMACOLOGICAL ACTIVITY OF A RENAL HERBAL PRODUCT MADE BY AN ORIGINAL METHODOLOGICAL APPROACH

Abstract

THE AIM of the investigation was to study pharmacological properties of a renal herbal product made on the basis of an original methodological approach to creation of complex phytomedicines. The access means a combination of herbals with special reference to biologically active substances (BAS) found in them. MATERIALS AND METHODS. The pharmacological properties of the decoction of these herbals were studied in experiments in rats given the decoction for a long time. The effects on the kidney functions were estimated by the diurnal diuresis and excretion with urine of creatinine, sodium and potassium. Antiinflammatory properties were estimated on models of carraginin edema of the rats’ pads and cotton granulomas. Antioxidant activity was estimated by the indices of the antioxidant and prooxidant activity under conditions of the formalin edema of the rats’ hind pads. Antimicrobial activity of the herbal decoction was determined by a modified technique of St.Ph. XIth edition. RESULTS. An analysis of the herbal product has established its ability to increase urination, reduce the intensity of acute and chronic inflammatory reaction, influence the processes of free radical oxidation and suppress the development of gram-positive and gram-negative pathogenic microflora. CONCLUSION. The results of pharmacological and microbiological investigations have shown that the original herbal product can be considered a perspective means for prophylactics and treatment of inflammatory diseases of the kidneys due to its high effectiveness and complex action in experiments. The approach used is shown to be perspective in making herbal mixtures.