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CОВРЕМЕННЫЙ ВЗГЛЯД НА ПАТОФИЗИОЛОГИЮ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗА: РОЛЬ ФАКТОРА РОСТА ФИБРОБЛАСТОВ 23 И KLOTHO

https://doi.org/10.24884/1561-6274-2011-15-4-11-20

Аннотация

Проанализированы современные представления о развитии и прогрессировании вторичного гиперпаратиреоза, основанные на новых данных о патофизиологии и молекулярных механизмах взаимодействия фосфат-регулирующих систем, в контексте значения фактора роста фибробластов 23 и Klotho

Об авторе

В. А. ДОБРОНРАВОВ
Санкт-Петербургскмй государственный медицинский университет им. акад. И.П. Павлова
Россия
Научноисследовательский институт нефрологии


Список литературы

1. Bricker N.S. On the pathogenesis of the uremic state. An exposition of the 'trade-off hypothesis'. N Engl J. Med 1972; 286 (20): 1093-1099

2. Portale A.A., Halloran B.P., Murphy M.M. et al. Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans. J. Clin Invest 1986; 77 (1): 7-12

3. Slatopolsky E., Finch J., Denda M. et al. Phosphorus restriction prevents parathyroid gland growth. High phosphorus directly stimulates PTH secretion in vitro. J. Clin Invest 1996; 97 (11): 2534-2540

4. Slatopolsky E. The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bone disorder. Kidney Int 2011; 79 (Suppl 121): S3-S8

5. Potts J.T. Parathyroid hormone: past and present. J. Endocrinol 2005; 187 (3): 311-325

6. Kumar R., Thompson J.R. The regulation of parathyroid hormone secretion and synthesis. J. Am Soc Nephrol 2011; 22(2): 216-224

7. Denda M., Finch J., Slatopolsky E. Phosphorus accelerates the development of parathyroid hyperplasia and secondary hyperparathyroidism in rats with renal failure. Am J. Kidney Dis 1996; 28 (4): 596-602

8. Martin D.R., Ritter C.S., Slatopolsky E. et al. Acute regulation of parathyroid hormone by dietary phosphate. Am J. Physiol Endocrinol Metab 2005; 289 (4): E729-E734

9. Kestenbaum B., Sampson J.N., Rudser K.D. et al. Serum phosphate levels and mortality risk among people with chronic kidney disease. Journal of the American Society of Nephrology. 2005; 16(2): 520-528

10. Hsu C.Y., Chertow G.M. Elevations of serum phosphorus and potassium in mild to moderate chronic renal insufficiency. Nephrology Dialysis Transplantation. 2002; 17(8): 1419-1425

11. Levin A., Bakris G.L., Molitch M. et al. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney International 2007; 71 (1): 31-38

12. Murayama A., Takeyama K., Kitanaka S. et al. Positive and negative regulations of the renal 25-hydroxyvitamin D3 1alpha-hydroxylase gene by parathyroid hormone, calcitonin, and 1 alpha,25(OH)2D3 in intact animals. Endocrinology 1999; 140(5): 2224-2231

13. Shimada T., Mizutani S., Muto T. et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci USA 2001; 98 (11): 6500-6505

14. Kurosu H., Ogawa Y., Miyoshi M. et al. Regulation of fibroblast growth factor-23 signaling by klotho. J. Biol Chem 2006 10; 281(10): 6120-6123

15. Kuro-o M., Matsumura Y., Aizawa H. et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997; 390(6655): 45-51

16. Liu S., Vierthaler L., Tang W. et al. FGFR3 and FGFR4 do not mediate renal effects of FGF23. J. Am Soc Nephrol 2008; 19 (12): 2342-2350

17. Hu M.C., Shi M., Zhang J. et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010; 24 (9): 3438-3450

18. Saito H., Kusano K., Kinosaki M. et al. Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1 alpha,25-dihydroxyvitamin D3 production. J. Biol Chem 2003; 278 (4): 2206-2211

19. Shimada T., Hasegawa H., Yamazaki Y. et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner Res 2004; 19(3): 429-435

20. Antoniucci D.M., Yamashita T., Portale A.A. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J. Clin Endocrinol Metab 2006; 91 (8): 3144-3149

21. Burnett S.M., Gunawardene S.C., Bringhurst F.R. et al. Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women. J. Bone Miner Res 2006; 21 (8): 1187-1196

22. Lopez I., Rodriguez-Ortiz M.E., Almaden Y. et al. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney Int 2011; 80 (5): 475-482

23. Tsujikawa H., Kurotaki X., Fujimori T. et al. Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol 2003; 17 (12): 2393-2403

24. Isakova T., Wahl P., Vargas G.S. et al. Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int 2011; 79 (12): 1370-1378

25. Gutierrez O., Isakova T., Rhee E. et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. Journal of the American Society of Nephrology 2005; 16 (7): 2205-2215

26. Liu S., Quarles L.D. How fibroblast growth factor 23 works. Journal of the American Society of Nephrology 2007; 18 (6): 1637-1647

27. Pria D., Torres P.U., Friedlander G. Latest findings in phosphate homeostasis. Kidney International 2009; 75 (9): 882889

28. Wolf M. Forging forward with 10 burning questions on FGF23 in kidney disease. Journal of the American Society of Nephrology 2010; 21 (9): 1427-1435

29. Berndt T., Kumar R. Novel mechanisms in the regulation of phosphorus homeostasis. Physiology 2009; 24 (1): 17-25

30. Berndt T., Thomas L.F., Craig T.A. et al. Evidence for a signaling axis by which intestinal phosphate rapidly modulates renal phosphate reabsorption. Proc Natl Acad Sci USA 2007; 104 (26): 11085-11090

31. Martin D.R., Ritter C.S., Slatopolsky E. et al. Acute regulation of parathyroid hormone by dietary phosphate. Am J. Physiol Endocrinol Metab 2005; 289 (4): E729-E734.

32. Ito N., Fukumoto S., Takeuchi Y. et al. Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans. J. Bone Miner Metab 2007; 25 (6): 419-422

33. Isakova T., Gutierrez O., Shah A. et al. Postprandial mineral metabolism and secondary hyperparathyroidism in early CKD. J. Am Soc Nephrol 2008; 19 (3): 615-623

34. Cha S.K., Ortega B., Kurosu H. et al. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci USA 2008; 105 (28): 9805-9810

35. Drueke T.B. Klotho, FGF23, and FGF receptors in chronic kidney disease: a yin-yang situation? Kidney Int. 2010; 78 (11): 1057-1060

36. Imura A., Tsuji Y., Murata M. et al. a-Klotho as a regulator of calcium homeostasis. Science 2007; 316 (5831): 1615-1618

37. Hu M.C., Shi M., Zhang J. et al. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J. 2010; 24 (9): 3438-3450

38. Hu M.C., Shi M., Zhang J. et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J. Am Soc Nephrol 2011; 22 (1): 124-136

39. Koh N., Fujimori T., Nishiguchi S. et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun 2001; 280 (4): 1015-1020

40. O'Brien S.P., Boulanger J.H., Liu S. et al. Decline in Klotho expression precedes FGF23 and PTH induction in the Jck mouse, a progressive genetic model of CKD-MBD [Abstract F-FC224]. J. Am Soc Nephrol 2009; 20: 54A

41. Kuro-o М. Phosphate and Klotho. Kidney International 2011; 79 (Suppl 121), S20-S23

42. Sitara D., Razzaque M.S., St-Arnaud R. et al. Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals. Am J. Pathol 2006; 169 (6): 2161-2170

43. Ohnishi M., Nakatani T., Lanske B. et al. Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase. Kidney Int 2009; 75 (11): 1166-1172

44. Morishita K., Shirai A., Kubota M. et al. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J. Nutr 2001; 131 (12): 3182-3188

45. Stubbs J.R., Liu S., Tang W. et al. Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice. J. Am Soc Nephrol 2007; 18 (7): 2116-2124

46. Ohnishi M., Nakatani T., Lanske B. et al. In vivo genetic evidence for suppressing vascular and soft-tissue calcification through the reduction of serum phosphate levels, even in the presence of high serum calcium and 1,25-dihydroxyvitamin d levels. Circ Cardiovasc Genet 2009; 2 (6): 583-590

47. Galitzer H., Ben-Dov I.Z., Silver J. et al. Parathyroid cell resistance to fibroblast growth factor 23 in secondary hyperparathyroidism of chronic kidney disease. Kidney Int 2010; 77 (3): 211-218

48. Komaba H., Goto S., Fujii H. et al. Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients. Kidney Int 2010; 77 (3): 232-238

49. Krajisnik T., Olauson H., Mirza M.A. et al. Parathyroid Klotho and FGF-receptor 1 expression decline with renal function in hyperparathyroid patients with chronic kidney disease and kidney transplant recipients. Kidney Int 2010; 78 (10): 1024-1032

50. Krajisnik T., Bjorklund P., Marsell R. et al. Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells. J. Endocrinol 2007; 195: 125-131

51. Ichikawa S., Imel E.A., Kreiter M.L. et al. A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis. J. Clin Invest 2007; 117 (9): 2684-2691

52. Hofman-Bang J., Martuseviciene G., Santini M.A. et al. Increased parathyroid expression of klotho in uremic rats. Kidney Int 2010; 78 (11): 1119-1127

53. Wetmore J.B., Liu S., Krebill R. et al. Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD. CJASN 2010; 5 (1): 110-116

54. Dusso A.S., Pavlopoulos T., Naumovich L. et al. p21WAF1 and transforming growth factor-б mediate dietary phosphate regulation of parathyroid cell growth. Kidney Int 2001; 59 (3): 855-865

55. Wells A. EGF receptor. Int J. Biochem Cell Biol 1999; 31: 637-643

56. Cozzolino M., Lu Y., Sato T. et al. A critical role for enhanced TGF-a and EGFR expression in the initiation of parathyroid hyperplasia in experimental kidney disease. Am J. Physiol Renal Physiol 2005; 289 (5): F1096-F1102

57. Raught B., Gingras A.C., James A. et al. Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells. Cancer Res 1996; 56 (19): 4382-4386

58. Arcidiacono M.V., Sato T., Alvarez-Hernandez D. et al. EGFR activation increases parathyroid hyperplasia and calcitriol resistance in kidney disease. J. Am Soc Nephrol 2008; 19 (2): 310-320

59. Dusso A., Arcidiacono M.V., Yang J. et al. Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality. J. Steroid Biochem Mol Biol 2010; 121 (1-2): 193-198

60. Chen C.D., Podvin S., Gillespie E. et al. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA 2007; 104 (50): 19796-19801

61. Bloch L., Sineshchekova O., Reichenbach D. et al. Klotho is a substrate for a-, в-and г-secretase. FEBS Lett 2009; 583 (19): 3221-3224

62. Chen C.D., Podvin S., Gillespie E. et al. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci USA 2007; 104 (50): 19796-19801

63. Cordero J.B., Cozzolino M., Lu Y. et al. 1,25-Dihydroxyvitamin D down-regulates cell membrane growth-and nuclear growth-promoting signals by the epidermal growth factor receptor. J. Biol Chem 2002; 277 (41): 38965-38971

64. Dusso A. Kidney disease and vitamin D levels: 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and VDR activation. Kidney Int 2011; Suppl. 1: 136-141

65. Tatsumi S., Segawa H., Morita K. et al. Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. Endocrinology 1998; 139 (4): 1692-1699

66. Jiang Y., Wang M. Overexpression of parathyroid pituitary-specific transcription factor (Pit) -1 in hyperphosphatemia-induced hyperparathyroidism of chronic renal failure rats. Chin Med J. (Engl) 2010; 123 (12): 1566-1570

67. Fliser D., Kollerits B., Never U. et al. Fibroblast growth factor 23 (FGF-23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study. J. Am Soc Nephrol 2007; 18 (9): 2600-2608

68. Titan S.M., Zatz R., Graciolli F.G. et al. FGF-23 as a predictor of renal outcome in diabetic nephropathy. Clin J. Am Soc Nephrol 2010; 6 (2): 241-247

69. Vervloet M., van Zuilen A.D., Blankenstijn P.J. et al. Fibroblast growth factor 23 is associated with proteinuria. J. Am Soc Nephrol 2010; 21: 186A

70. Gutierrez O.M., Mannstadt M., Isakova T. et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J. Med 2008; 359 (6): 584-592

71. Vervloet M., Larsson T. Fibroblast growth factor-23 and Klotho in chronic kidney disease. Kidney Int 2011; Suppl. 1: 130-135

72. Mirza M.A., Larsson A., Lind L. et al. Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community. Atherosclerosis 2009; 205 (2): 385-390

73. Mirza M.A., Hansen T., Johansson L. et al. Relationship between circulating FGF-23 and total body atherosclerosis in the community. Nephrol Dial Transplant 2009; 24 (10): 31253131

74. Yilmaz M.I., Sonmez A., Saglam M. et al. FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease. Kidney Int 2010; 78 (7): 679-685

75. Kirkpantur A., Balci M., Gurbuz C.A. et al. Serum fibroblast growth factor-23 (FGF-23) levels are independently associated with left ventricular mass and myocardial performance index in maintenance haemodialysis patients. Nephrol Dial Transplant 2011; 26 (4): 1346-1354

76. Kuro-o M. Klotho as a regulator of oxidative stress and senescence. Biol Chem 2008; 389 (3): 233-241

77. Kusaba T., Okigawa M., Matui A. et al. Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity. Proc Natl Acad Sci USA 2010; 107 (45): 19308-19313

78. Nagai R., Saito Y., Ohyama Y. et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci 2000; 57 (5): 738-746

79. Doi S., Zou Y., Togao O. et al. Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J. Biol Chem 2011; 286 (10): 8655-8665

80. Takeshita K., Fujimori T., Kurotaki Y. et al. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation 2004; 109 (14): 17761782

81. Maschio G., Tessitore N., D'Angelo A. et al. Early dietary phosphorus restriction and calcium supplementation in the prevention of renal osteodystrophy. Am J. Clin Nutr 1980; 33 (7): 1546-1554

82. Alfrey A.C. Effect of dietary phosphate restriction on renal function and deterioration. Am J. Clin Nutr 1988; 47 (1): 153-156


Рецензия

Для цитирования:


ДОБРОНРАВОВ В.А. CОВРЕМЕННЫЙ ВЗГЛЯД НА ПАТОФИЗИОЛОГИЮ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗА: РОЛЬ ФАКТОРА РОСТА ФИБРОБЛАСТОВ 23 И KLOTHO. Нефрология. 2011;15(4):11-20. https://doi.org/10.24884/1561-6274-2011-15-4-11-20

For citation:


DOBRONRAVOV V.A. CURRENT VIEW ON THE PATHOPHYSIOLOGY OF SECONDARY HYPERPARATHYROIDISM: ROLE OF FIBROBLAST GROWTH FACTOR 23 AND KLOTHO. Nephrology (Saint-Petersburg). 2011;15(4):11-20. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-4-11-20

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