THE DYNAMICS OF ACETATEMIA WITH USING BICARBONATE AND ACETATE-FREE DIALYSATE IN PATIENTS WITH ACUTE KIDNEY INJURY
https://doi.org/10.24884/1561-6274-2011-15-4-34-38
Abstract
THE AIM of this study was to examine relative effect of SLEDD (sustained low-efficiency daily dialysis) with standard bicarbonate and with acetate-free dialysate on acetatemia dynamics and haemodynamic stability in patients with acute kidney injury (AKI) after cardiac surgery. PATIENTS AND METHODS. Thirty-five patients with AKI., who requires renal replacement therapy (RRT), were divided into two 2 groups. 46 SLEDD with bicarbonate dialysate (contains 3 mmol/l of acetate) were performed in group A (n=18). 52 SLEDD with acetate-free dialysate «Krebsol» were performed in group B. Serum acetate level, acid-base balance factors and electrolytes, episodes of intradialisis hypotension and arrhythmias were evaluated. RESULTS. After SLEDD with bicarbonate dialysate initial acetate concentration increased averagely 4 times. On the contrary, after SLEDD with acetate-free dialisate acetate range didn't alter. In both groups was achieved decrease of azotaemia and permanent correrction of electrolytic homeostasis and acid-base balance. At the same time usage of acetate-free dialysate significantly modulated hemodynamic complications. CONCLUSION. The study has shown that even «small» acetate concentrate in standard bicarbonate dialysate may become a cause of significant acetatemia and, as a consequence, can induce hemodynamic complications at SLEDD in patients with AKI. Usage of SLEDD with acetate-free dialysate reduced risk of intradialisis complications development
About the Authors
Z. M. UNAROKOV
Новосибирскикий научно-исследовательский институт патологии
кровообращения им. акад. Е.Н. Мешалкина
Russian Federation
Russian Federation
T. V. MUKHOEDOVA
Новосибирскикий научно-исследовательский институт патологии
кровообращения им. акад. Е.Н. Мешалкина
Russian Federation
Russian Federation
O. V. SHUVAEVA
Институт неорганической химии им. А.В.Николаева Сибирского отделения РАН
Russian Federation
Russian Federation
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Review
For citations:
UNAROKOV Z.M., MUKHOEDOVA T.V., SHUVAEVA O.V. THE DYNAMICS OF ACETATEMIA WITH USING BICARBONATE AND ACETATE-FREE DIALYSATE IN PATIENTS WITH ACUTE KIDNEY INJURY. Nephrology (Saint-Petersburg). 2011;15(4):34-38. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-4-34-38
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