NEPHROPROTECTIVE AND СARDIOPROTECTIVE EFFECTS ESTIMATION OF LOW-PROTEIN DIET WITH KETOSTERIL LONG TERM ADMINISTRATION
https://doi.org/10.24884/1561-6274-2011-15-4-45-50
Abstract
THE AIM. Research of low-protein diet (LPD) with Ketosteril long-term administration effect on cardio-vascular system and rats values with experimentally decreasing of functional nephron quantity. MATERIAL AND METHODS. Work is completed on Wistar male rats with 5/6 nephrectomy (NE). During 4 months after NE one group of rats received standard diet (20.16% animal protein), another group - LPD with 10% Ketosteril. Control rats received either standard or low-protein diet. RESULTS. Administration of LPD with Ketosteril retarded experimental uremia progression, reduced phosphatemia, proteinuria, prevented triglyceride concentration increasing in serum. Experimental LPD cardioprotective effect included improving mean arterial pressure and prevention myocardium weight rising in rats with NE. RESULTS. Long-term usage of qualitatively and quantitatively balanced low- protein makes reno- and cardioprotective effects on animals with experimental kidney failure
About the Authors
G. T. IVANOVA
Институт физиологии им. И.П. Павлова РАН
Russian Federation
Russian Federation
A. G. KUCHER
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
O. N. BERESNEVA
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
M. M. PARASTAYEVA
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
A. V. SMIRNOV
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
D. V. CHEREDNICHENKO
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
L. V. KOTENKO
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
I. G. KAYUKOV
Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
IVANOVA G.T., KUCHER A.G., BERESNEVA O.N., PARASTAYEVA M.M., SMIRNOV A.V., CHEREDNICHENKO D.V., KOTENKO L.V., KAYUKOV I.G. NEPHROPROTECTIVE AND СARDIOPROTECTIVE EFFECTS ESTIMATION OF LOW-PROTEIN DIET WITH KETOSTERIL LONG TERM ADMINISTRATION. Nephrology (Saint-Petersburg). 2011;15(4):45-50. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-4-45-50
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