GLYCOSYLATED HEMOGLOBIN IS AN IMPORTANT PROGNOSTIC INDICATOR IN NEPHROLOGY
https://doi.org/10.24884/1561-6274-2005-9-3-60-66
Abstract
THE AIM of the work was to establish the ways of using the level of glycosylated hemoglobin (HbA1c) in nephrology. PATIENTS AND METHODS. The following patients were examined: 34 patients with diabetic nephropathy (DN), 11 patients with chronic glomerulonephritis (CGN) with the initial stage of chronic renal failure (CRF) and 11 with terminal renal failure. The method of isoelectrical focusing in the boratepolyolic system was used for determination of the HbA1c level. RESULTS. Glomerular filtration rate, blood creatinine level were found to substantially influence the proteinuria level (24P) in diabetes mellitus patients. A substantial effect of the HbA1c level was also found on the duration of CRF in CGN patients and on the main parameters of dialysis therapy. For example the influence of the HbA1c level on hemodialysis adequacy index according to urea (kt/v) was 65.6%, on the blood perfusion rate 61.3%, on the blood perfusion volume 89.1%. CONCLUSION. The HbA1c level might be a prognostic parameter for 24P in patients with DN and for the latent and initial CRF in patients with CGN. The data obtained allow HbA1c to be recommended as an additional indicator of a reliable control of the quality of programmed hemodialysis.
About the Author
V. A. Korolev
Крымский государственный медицинский университет им.С.И.Георгиевского
Ukraine
Ukraine
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Review
For citations:
Korolev V.A. GLYCOSYLATED HEMOGLOBIN IS AN IMPORTANT PROGNOSTIC INDICATOR IN NEPHROLOGY. Nephrology (Saint-Petersburg). 2005;9(3):60-66. (In Russ.) https://doi.org/10.24884/1561-6274-2005-9-3-60-66
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